The San Francisco 49ers ruled out any chance that Mario Manningham would be ready for the start of the regular season after placing the injured wide receiver on the physically unable to perform/reserve list, coach Jim Harbaugh announced Sunday.
Manningham suffered a torn ACL and PCL in his knee during a loss to the Seattle Seahawks in December. Moving Manningham from the PUP/active to the PUP/reserve list means that he is ineligible to return until the 49ers' seventh game of the season against the Tennessee Titans.
The 49ers are hoping that Manningham will be able to practice later this month. Their receiving corps also is missing Michael Crabtree, who is sidelined with an Achilles' injury.
The 27-year-old Manningham had 42 receptions for 449 yards and one touchdown in 12 games last season, his first with the 49ers after four years with the New York Giants.