Lipscomb (14-14, 9-8 Atlantic Sun) opened the game with a barrage of six straight 3-pointers to take a lead that was never challenged.
Malcolm Smith contributed 20 points and eight rebounds, while Talbott Denny added 11 for the Bisons, who shot 50 percent from the field, hitting 15 of 30 from 3-point range, and 17 of 22 from the free throw line in the win. Martin Smith also had seven rebounds.
FGCU (19-11, 13-4), which trailed 58-38 at the break, kept pace in the second half but couldn't erase the 20-point deficit.
Brett Comer scored 27 points for the Eagles, who hung on to a share of first place atop the conference standings despite the loss, after co-leader Mercer also fell Thursday night.