Sometimes, it's about quality, not quantity. There weren't many injuries in Week 15 with fantasy relevance, but three of them are rather significant, and likely to affect fantasy championships …
Tony Romo, bruised thumb
You can't exactly blame Romo's atrocious Week 15 performance on the thumb injury. He misfired early and often before the injury occurred, failing to complete a pass until he found Jason Witten for eight yards with 13:00 remaining in the second quarter. There's actually an item on the Yahoo! NFL Rumors page right now suggesting that he was jinxed by Jessica Simpson. Whether or not there's validity to this is unclear. But it would be nice to see her disciplined, just in case.
As for the thumb, it clearly bothered Romo. You can't really worry about him missing the Cowboys' Week 16 game – according to the Dallas Morning News, Romo "downplayed the injured thumb and expects to play Saturday at Carolina." His effectiveness, however, is a definite worry. You'll have to monitor this all week.
Justin Fargas, MCL sprain
The San Jose Mercury News has reported the injury as a medial collateral ligament sprain in Fargas' right knee. An MRI is expected today. This clearly has the potential to end Fargas' season, though we'll know more later in the week. As we always do. About everything.
If Fargas misses Week 16, the 2.1 percent-owned Dominic Rhodes could be your Raiders starting running back, although you can't really like him at Jacksonville. If Fargas doesn't play another snap this season, he'll finish with 1,009 rushing yards and 4.5 yards per carry.
Jeremy Shockey, broken fibula
Clearly, the Giants training staff has been grossly negligent where fibulas are concerned. This is New York's third broken fibula over the past five weeks (Derrick Ward and Mathias Kiwanuka possess the others). This injury will end Shockey's season and leave his owners searching the waiver wire for a viable fantasy tight end. The universally un-owned Kevin Boss actually caught two passes for 31 yards and a touchdown in Shockey's absence, but I'd still prefer the 33.1 percent-owned Tony Scheffler or the 43.8 percent-owned Greg Olsen.
Kellen Clemens (ribs) and Laveranues Coles (ankle) also suffered injuries in Week 15. In Coles' case, it actually sounds like he was injured before the game, by a rogue training table. Neither should be relied on in Week 16. Chad Pennington could very well be your Jets quarterback (again) in Week 16 at Tennessee. In leagues that start two QBs, this matters.