Ryan Rayburn and Lonnie Chisenhall homered for the Indians, whose winning streak ties a season high. Three of Cleveland's last four games have gone extra innings, including a 13-inning win over Detroit on Wednesday night.
After two hits and a walk loaded the bases in the 13th, Santana came to plate against Troy Patton (0-1) with a .148 batting average. He pulled a sharp grounder inside the third-base line, only his third hit in 32 at-bats with two outs and runners on.
Josh Outman (4-0) pitched two scoreless innings and Scott Atchison got three outs for his first save.