PHOENIX -- Paul Goldschmidt seems to be at his best in clutch situations, and it showed again in his third career two-home run game on Friday night.
Goldschmidt broke a 3-3 tie with a two-run homer in the fifth inning and added a 457-foot solo shot in the sixth in Arizona's 11-5 victory over Cincinnati at Chase Field . He has 12 home runs that have given the Diamondbacks a lead this season, a major league high.
"Everyone wants to be in that spot. You are going to fail, or not come through, more times than you are not. That's just how the game is, especially as a hitter," Goldschmidt said.
"Regardless of whether you are doing well or not, you just kind of forget about the past and try to have a good at-bat and hopefully it works out."
Goldschmidt leads the National League with 65 RBIs and is tied for second with 19 homers after hitting 20 last year. He had a walk-off homer in the ninth inning of a 3-2 victory over Miami on Tuesday.
"I wouldn't know. I don't look at anything, any stats. They are what they are, but that stuff is in the past. You have to focus on that game and that at-bat," Goldschmidt said.
The Diamondbacks, who had 14 runs in their previous six games, won their third straight to game to improve to 40-33.
Jason Kubel tied a career high with four hits and scored three runs, Didi Gregorius had three hits against his former team, Martin Prado had two sacrifice flies and Gerardo Parra homered.
Joey Votto had three hits, including his 13th home run, and was a triple short of the cycle for the Reds (44-31), who have lost three of their last four and have scored 19 runs in their last seven games.
Jay Bruce hit his 16th homer of the season and 150th of his career for Cincinnati.
Willie Bloomquist, who had a two-run single in the second, singled to open the fifth off Johnny Cueto (4-1) before Goldschmidt connected on a slider to right-center field.
"He was getting balls over the heart of the plate. His slider wasn't as sharp. The one he threw to Goldschmidt that spun like a cement mixer instead of really breaking. He was almost Johnny tonight," Cincinnati manager Dusty Baker said.
Cueto gave up seven runs and 11 hits in his second start since coming off his second stint on the disabled list with a shoulder strain. He had given up seven runs in his previous six career starts against Arizona.
"Things did not go well. It is just one outing but a bad outing. I have a lot more outings so I have to keep my head up and continue," Cueto said.
Will Harris (1-0) got the victory after striking out the only batter he faced with runners on first and third for the final out of the fifth inning, after the Reds scored twice to tie it at 3.
Gerardo Parra started the game with a homer to right field, his fifth leadoff home run of the season, and Bloomquist's two-out, two-run single with the bases loaded in the second made it 3-0.
Bruce's home run off Wade Miley, his sixth against a left-hander hit season, cut it to 3-1 in the fourth. Bruce leads the majors with 40 homers against lefties since 2010.
In the fifth, Votto doubled in a run and Brandon Phillips had an RBI when the Reds tied the score at 3 and knocked Miley out of the game.
NOTES: Diamondbacks RHP Zeke Spruill pitched a scoreless sixth inning in his major league debut in sixth inning after being recalled from Triple-A Reno to add bullpen length. Spruill was 3-3 with a 4.06 ERA in nine starts at Reno. IF Josh WIlson was designated for assignment to create room on the roster. Wilson was hitting .200 with one homer and four RBIs in 60 at-bats. ... Cincinnati had won 12 of its last 15 games at Chase Field entering the series opener. ... Phillips leads the majors with 24 go-ahead RBIs and 13 game-winning RBIs. ... RHP Mike Leake, Cincinnati's first-round pick in the 2009 draft out of nearby Arizona State, will enter his Saturday start with a 5-0 record and a 1.66 ERA in six career starts against the Diamondbacks, limiting them to a .143 batting average. ... The Diamondbacks announced RHP Randall Delgado will start the final game of the series Sunday, with RHP Brandon McCarthy (shoulder) on the disabled list and RHP Ian Kennedy serving his 10-game suspension.