The Colorado Rockies hope De La Rosa can add another victory against the Giants to his impressive stretch as they try to avoid losing back-to-back home games for the first time this season Thursday.
Colorado (26-21) managed five hits in a 5-1 loss to San Francisco on Wednesday after recording at least 11 in each of its previous three games.
The Giants (29-18) were powered by three solo home runs, winning despite being without Buster Posey for a second straight contest due to nerve irritation in his lower back.
Hunter Pence's fourth homer of the season extended his hitting streak to eight. He's batting .355 during that stretch and has gone 17 for 36 with 10 RBIs in his last 10 games against Colorado.
Manager Bruce Bochy said Posey has a chance to be back in the lineup Thursday but San Francisco now has to worry about Matt Cain and reliever Santiago Casilla, who are scheduled for MRIs after exiting Wednesday's game with strained right hamstrings.
"The win was great," Pence said. "But it's a huge blow to lose Cain and Casilla."
De La Rosa (5-3, 4.14 ERA) had been 1-3 with an 8.00 ERA in his previous six starts against San Francisco before his run of five straight victories began with an 8-2 win over the Giants on April 21. He limited the Giants to one run over five innings.
The left-hander has posted a 2.03 ERA in his last five outings after recording a 7.58 mark through his first four starts. He gave up one hit over seven scoreless innings in a 3-1 victory over San Diego on Friday.
"He gave us just what we were looking for and hopefully it can get us going," outfielder Carlos Gonzalez said.
Gonzalez, whose 12 doubles are tied for second on the team, is day to day after leaving in the eighth inning Wednesday due to inflammation in his left index finger.
Colorado may be able to get back on track offensively Thursday considering Tim Hudson's track record at Coors Field. Though he's been among the better pitchers in baseball this season, he's 0-2 in six career starts in Denver with a 7.41 ERA - his third-highest mark at any current park.
Hudson (4-2, 2.09) allowed a season-high four earned runs, including home runs to Justin Morneau and Wilin Rosario, over 7 1-3 innings of a 5-4 home win over Colorado on April 13.
The right-hander threw a bullpen session Tuesday without any issues after missing his scheduled start against Miami on Friday due to a strained left hip.
Hudson gave up two runs over six innings and didn't get a decision in his most recent outing, a 7-4 road win over the Los Angeles Dodgers on May 11. It was the first time in eight starts this season that he failed to complete at least seven innings.