New York Giants cornerback Prince Amukamara sustained a high ankle sprain in the first quarter of Friday's exhibition game against the visiting Chicago Bears.
Amukamara could miss several weeks, according to ESPN.com.
The injury occurred while Amukamara was defending Bears wide receiver Devin Hester on an end-around play with less than five minutes left in the first quarter. Amukamara was carted off the field after the next play when he tackled Bears wide receiver Brandon Marshall.
"It is not a fracture," coach Tom Coughlin said after X-rays on Amukamara's ankle came back negative. "They were saying high ankle. Dr. (Russ) Warren thought it was mild. I don't like that term 'high ankle.' If it a mild sprain, perhaps, it is not going to take as much time getting back."
Last year, starting cornerback Terrell Thomas tore his right ACL against the Bears in an exhibition game. Amukamara, then a rookie first-round draft pick, replaced Thomas. He is still rehabbing his knee.
Three of the Giants' top six cornerbacks are out with injuries: Thomas, Amukamara and third-round pick Jayron Hosley (turf toe).
Amukamara missed nine games last year with a broken left foot.
Bruce Johnson, Michael Coe and Justin Tryon are likely the leading candidates to start while Amukamara is out.
Also, linebacker Mathias Kiwanuka strained his groin during the first half.
The Giants begin the regular season Sept. 5 against the Dallas Cowboys.