Seattle Seahawks (4-0) at Indianapolis Colts (3-1)
Sunday, 1:00 p.m. ET, at Lucas Oil Stadium, Indianapolis - TV: FOX
*TV announcers: Kevin Burkhardt, John Lynch, Erin Andrews
*Keys to the game: Colts OLB Robert Mathis leads the NFL with 7.5 sacks and will certainly take note of the tremendous pressure the Texans were able to put on Seahawks QB Russell Wilson last week. Seattle might get C Max Unger back in the lineup, but is playing with a pair of backup tackles. Offensive coordinator Darrell Bevell finally started moving the pocket for Wilson in the second half last week and will continue to take a handful of deep shots each week in an effort to keep defenses from stacking the box against RB Marshawn Lynch. The Colts continue to work RB Trent Richardson into the mix and need to maintain offensive balance. Seattle's pass rush continues to get healthier with LB Bruce Irvin back from suspension and the defense has produced seven interceptions. However, the pass rush has been inconsistent and Colts QB Andrew Luck will have an opportunity to move the ball against man coverage if his protection holds up. TE Coby Fleener is coming off a five-catch game at Jacksonville and Seattle's linebackers struggled to contain Texans TE Owen Daniels last week.
*Matchup to watch - Seahawks OTs Paul McQuistan and Michael Bowie vs. Colts OLB Robert Mathis: Mathis plays a different role than Houston's J.J. Watt, who blew up Seattle's offensive line from his interior position last week, but he will present matchup problems in his own right. McQuistan is a natural guard who lacks the foot speed to content with elite speed rushers and Bowie is a seventh-round rookie undergoing a trial by fire.
*Player spotlight - Seahawks DT Clinton McDonald: McDonald didn't make the 53-man roster out of training camp, but we re-signed after Week 1 and is coming off consecutive strong games while providing a surprising interior push.
*Fast facts: The Seahawks are 4-0 for the first time in franchise history. ... The Colts have rushed for 100-plus yards in each of the first four games this season, the first time they've accomplished that feat since 1988.
WHO WILL WIN AND WHY
The Seahawks have as many interceptions (four) as touchdowns allowed in 11 red zone possessions by opponents this season and can keep the game within reach with their defense. But Seattle has already pulled two Houdini acts on the road and Indianapolis should be able to control field position.
*Our pick: Colts 23-17