TALLAHASSEE, Fla. -- Jameis Winston's amazing Labor Day night debut at hostile Heinz Field was the stuff of legend.
His first home game in a Florida State uniform, however, was slightly more pedestrian -- but only for a quarter.
The redshirt freshman quarterback showed signs of both rust and nerves Saturday following No. 10 Florida State's unusually long layoff since opening the season 12 days ago at Pittsburgh.
But Winston settled down following an interception and a bone-crunching sack in the first 15 minutes to complete 15-of-18 passes for 214 yards passing and three total touchdowns to lead the Seminoles past Nevada, 62-7.
Winston was 25-for-27 for 365 yards and five touchdowns against Pitt, marking the best debut by a freshman quarterback in school history.
The Seminoles are 2-0 for the third consecutive season and improved the school's all-time record against Mountain West Conference opponents to 3-4 while playing the Wolf Pack for the first time.
Nevada (1-2) played without starting quarterback Cody Fajardo, who was ruled out hours before kickoff because of a knee injury he sustained last week in the Wolf Pack's victory over UC Davis.
Having Fajardo, an All-MWC selection on Saturday probably would not have mattered for Nevada.
Winston and the Seminole defense, which was led by six tackles each from Terrance Brooks and Lamarcus Joyner on defense, were simply too much.
Winston let Florida State's running game take over in this one, as Devonta Freeman, James Wilder Jr. and recently converted safety Karlos Williams stole the show.
All three scored as Williams led the way with eight carries for 110 yards and a touchdown, while Freeman rushed for 109 yards on nine carries and Wilder finished with 45 yards on six rushestotes.
Winston also ran for a 10-yard touchdown as part of a 31-point third quarter.
Nevada trailed only 17-7 at halftime, but watched helplessly as Florida State blew the game open after that, scoring three touchdowns in the first 3:43 of the second half.
The Wolf Pack's ugly start out of the locker room was eerily similar to their opener against No. 16 UCLA, when they hung with the Bruins through two quarters and were behind, 17-13, at halftime.
Nevada was then outscored, 41-8, in the second half and lost, 58-20.
The Wolf Pack's run defense, which has given up 891 yards through three games, was once again a glaring weakness.
Freeman capped off the first drive of the second half with a six-yard touchdown run.
Williams, the No. 5 overall recruit in the nation a year ago, then took the first handoff of his career around right end on the Seminoles' next drive and galloped 65 yards untouched for a score.
Wilder helped Florida State pour it on in the third quarter with a one-yard scoring run and Winston finished off the onslaught with his touchdown run.
With Florida State ahead, 45-7, late in the third quarter, Winston was pulled for backup Jacob Coker, who completed 2-of-4 passes for 26 yards.
Stepping in for Fajardo was Devin Combs, a 6-2, 220-pound junior from Oakdale, Calif., who had never started a game for Nevada and only saw action twice last season.
Following an opening-drive field goal by Florida State's Roberto Aguayo, Combs led the Wolfpack to an early 7-3 lead when Winston made the first mistake of the game, throwing an interception to Bryson Keeton deep in Seminoles territory.
That led to Combs hooking up with Brandon Wimberly for an 11-yard touchdown early in the second quarter.
Nevada's 10-7 lead lasted for all of eight minutes.
Winston rallied his team two possessions later with a 24-yard touchdown pass to Kenny Shaw, who hauled in the throw with one hand and a defender draped all over him.
Two minutes later after a hold by Florida State's defense, Winston and the offense tacked on a second passing score on the Seminoles' final drive before the half.
The 6-4, 225-pound former No. 1 high school quarterback recruit in the nation found junior receiver Rashad Greene on a back-shoulder fade route, also from 24 yards, and Greene made a beauty of a catch in the end zone to give Florida State a 17-7 halftime lead.
Combs, who was 6-for-9 for 37 yards and a score, didn't return after halftime (knee injury), paving the way for redshirt freshman Tyler Stewart to start the second half.
Stewart wasn't very effective, finishing 7-of-14 for 49 yards and an interception by Tyler Hunter.
Chris Solomon led the Wolf Pack with 26 carries for 108 yards.
Before Nevada, Florida State's last victory over a Mountain West opponent was a 17-8 win over Utah State in 1975, while its last game against a MWC foe was 1977, when the Seminoles were thumped by San Diego State, 41-16.
NOTES: Roberto Aguayo added a 33-yard field goal to cap a 31-point third quarter for Florida State. ... Freshman fullback Freddie Stevenson tacked on the Seminoles' second-to-last score of the game in the fourth quarter from one yard out, while freshman Ryan Green had Florida State's final touchdown from a yard out with 2:48 left to play. ... Brandon Wimberly's first catch for Nevada on its opening play marked his 43rd straight game with a reception, extending the longest active streak in the nation. ... Sebastian Janikowski, the Oakland Raiders kicker and former Florida State standout, was one of eight new members inducted into the Seminoles' Athletics Hall of Fame on Friday. ... Florida State, which is 34-2 in its last 36 home openers, last lost a home opener in 2009, when it fell to rival Miami, 38-34 ... Had he played, Cody Fajardo, a junior, would have only needed 43 yards rushing to become the second Nevada quarterback in school history to run for 2,000, joining Colin Kaepernick of the San Francisco 49ers (4,112 career yards) in the Wolf Pack record book.