Huff is the second receiver drafted by the Eagles on Friday. They took Vanderbilt wideout Jordan Matthews in the second round at No. 42.
Huff played for Eagles coach Chip Kelly at Oregon. He had 62 catches for 1,140 yards and 12 touchdowns as a senior.
The 5-foot-11, 206-pound Huff is considered a good blocker with an explosive burst. He also can bolster Philadelphia's special teams as a returner.
The Eagles traded the 83rd overall pick to Houston for a fourth-rounder (No. 101) and a fifth-rounder (141).