NEW YORK -- Ryan Doumit had seen five sliders already from Phil Hughes and with one out in the seventh inning of a tie game, he was anticipating another one.
When the next slider came, Doumit did not miss it, hitting a tie-breaking solo home run that lifted the Minnesota Twins to a 4-1 victory over the New York Yankees on Saturday at Yankee Stadium.
"I was thinking back of how's pitched me and how he's been pitching everybody else," Doumit said. "I thought there was a pretty good chance I might get a slider. I just told myself to see it up and I got one that I got a pretty good part of the bat on.
"That was a very effective pitch for him throughout the game. "It was the first time that I've faced Hughes where he's thrown that back door slider, and he was nasty and got me the first two at-bats.
Added Twins manager Ron Gardenhire: "He just left one up enough. It looked like he was trying to get it down or back door it, which he had been doing very well all day to our lefties ... get a couple of strikes and back door the slider, which is something we know that's what he does."
Trevor Plouffe and Pedro Florimon also hit home runs for the Twins, who won for the second time in 13 games and for only the eighth time in 39 games in New York. The Twins hit three home runs for the time since June 30.
Samuel Deduno (5-4) became the first Minnesota starter to go at least seven innings since June 27, holding the Yankees to one run and seven hits in seven innings.
Deduno avoided facing former Robinson Cano, his Dominican Republic WBC teammate, with men on base twice and went after the All-Star second baseman with fastballs.
"When you see Robinson Cano taking swings the way he did off some of those pitches, it says something about the kind of movement he had," Doumit said.
Added Gardenhire: "Sammy was fantastic. The ball was moving all over the place, evidenced by their swings."
Deduno had the lead for only one inning and that came after Doumit's ninth home run on a 2-and-2 slider from Hughes (4-9) that cleared the right field wall.
The hit might have been a double or an out in Minnesota, but when Doumit reached over to get the pitch, he drove it enough over the short right field wall.
"In this ballpark, that's a homer," Gardenhire said. "In our ballpark, that's off the wall or an out, so good ballpark for him to do that."
Deduno equaled the longest outing of his career by working out of trouble most of the afternoon, holding the Yankees to two hits in 10 at-bats with runners on base.
The biggest instance came in the seventh.
Pinch hitter Travis Hafner led off the Yankee seventh with a double that center fielder Aaron Hicks came a few steps shy of catching. Pinch runner Eduardo Nunez took third on a groundout by Austin Romine, but he was stranded when Gardner grounded back to Deduno.
"Everything was around the plate," Deduno said. "Everything was working."
Deduno threw a season high 106 pitches before Casey Fien pitched a scoreless eighth after allowing a leadoff single to Ichiro Suzuki. Glen Perkins allowed only a single in the ninth and earned his 21st save.
The Twins had a call go against them in the eighth when Clete Thomas was called for interference after Hughes' throw hit him in the back. Gardenhire disagreed and was ejected by plate umpire Vic Carapazza.
After Gardenhire was ejected for the third time this season, Florimon hit a 2-and-2 slider into the second deck and right field and Hughes was lifted.
Hughes allowed four runs and five hits over 7 1/3 innings. He tied a season high with 10 strikeouts, but also gave up three home runs for the second time this season.
"I thought that he threw the ball exceptionally well, except for a few mistakes," New York manager Joe Girardi said.
The Yankees had a three-game winning streak snapped, lost for the third time in 12 games and fell to 2-29 when scoring two runs or fewer.
New York's only run came on a one-out single by Cano in the first that deflected off Deduno's foot and scored Ichiro Suzuki, who had doubled.
NOTES: In an interview with Siruis/XM host Jim Bowden, New York general manager Brian Cashman said OF Curtis Granderson could return in early August. Granderson has played only eight games due to two stints on the disabled list because of a broken right hand. ... The Yankees did not have any updates on SS Derek Jeter (right quad). ... 3B Alex Rodriguez was slated to appear in one game of Class A Tampa's doubleheader on Saturday. ... Twins rookie OF Oswaldo Arcia was given the day off after striking out four times Friday. He has 11 strikeouts in his last 13 at-bats and has three hits in his last 28 at-bats. ... C Joe Mauer's 29 doubles before the All-Star break are the second-most in Minnesota history, surpassing Kirby Puckett (1989) and Matt Lawton (2000), who each had 28 before the break. Chuck Knoblauch had 37 in 1994. ... Ron Gardenhire was ejected for the 65th time as a manger.