CHICAGO -- Nate Schierholtz's fourth-inning home run gave starting right-hander Travis Wood all the runs he needed as the Chicago Cubs topped the St. Louis Cardinals 2-1 on Tuesday night.
Schierholtz' two-run shot to center off Cardinals starter Lance Lynn also scored Alfonso Soriano as the Cubs won their second straight.
Lynn (5-1) worked seven innings and allowed four hits and two earned runs. He walked one and struck out eight in his first career loss to the Cubs in five decisions.
Lynn also had a 10-game winning streak end. It was the longest active run in the major leagues dating to Sept. 9, 2012.
The loss snapped the Cardinals' six-game winning streak.
Wood (3-2) departed with two out in the seventh after throwing 114 pitches. He allowed one earned run and nine hits while walking two and striking out eight.
Reliever Carlos Marmol gave up a base hit to Carlos Beltran but got Matt Holliday to fly out to center to end the inning on the way to 1 1/3 scoreless innings of work.
Schierholtz was 1 for 3 and Soriano was 2 for 3 with a run scored. Yadier Molina went 2 for 4 for St. Louis.
Cubs right-hander Kevin Gregg worked the ninth for his fifth save.
Schierholtz's two-run homer in the fourth put the Cubs on top 2-1. After Lynn struck out Starlin Castro and Anthony Rizzo, Soriano singled to right and Schierholtz sent a 3-1 pitch to straightaway center for his fourth home run.
Allen Craig gave the Cardinals a 1-0 lead in the second. Leading off the inning, he drove a 2-2 pitch from Wood to left for his second home run of the season and second in four days.
Wednesday's series finale features two right-handers, the Cardinals' Jake Westbrook (2-1, 1.07 ERA) and the Cubs' Carlos Villanueva (1-2, 2.85 ERA).
Both teams are off Thursday. The Cubs open a three-game series Friday in Washington. The Cardinals are home for three against Colorado.
NOTES: The Cardinals activated first baseman Matt Adams from the 15-day disabled list. Adams, who was out with a right oblique strain, batted .250 (3 for 12) with a double and two RBIs in two rehab games for Double-Springfield. ... Entering Tuesday, St. Louis starters had a major league-best 2.21 ERA in 31 starts. The Detroit Tigers were next at 3.09. ... The Cubs encourage fans to wear pink on Wednesday in support of breast cancer awareness. Proceeds from Wednesday's 50-50 raffle will benefit breast mammograms for underinsured women. ... In Monday's 9-2 victory over Texas, the Cubs posted season highs in runs and walks drawn (seven), and a five-run fourth was their biggest inning of the season. ... Entering Tuesday, Wood was the first Cubs left-hander in 65 years to begin the season with six straight quality starts. The last was Johnny Schmitz in 1948.