The Indianapolis Colts waived rookie quarterback Chandler Harnish and linebacker Jerry Brown, while signing former Pittsburgh Steelers tight end Weslye Saunders.
Tight end Dominique Jones was released from the practice squad.
Harnish was the final pick of the draft in April, known as "Mr. Irrelevant," and has been inactive for the Colts' first five games this season.
Saunders was signed by the Steelers as an undrafted rookie in 2011 and went on to catch four passes for 29 yards and one touchdown. He was waived last week after being suspended for the first four games of the season for taking a banned substance.