Indianapolis Colts quarterback Andrew Luck outdueled Denver Broncos quarterback Peyton Manning, manufacturing a 39-33 win Sunday night that spoiled Manning's homecoming.
Luck threw three touchdown passes, rushing for one more as the Broncos lost for the first time. The Kansas City Chiefs are the lone remaining undefeated team.
Manning was sacked four times with one interception and a lost fumble as Broncos kick returner Trindon Holliday fumbled twice.
Manning completed 29 of 49 passes for 386 yards and three touchdowns, but wasn't as sharp as Luck.
Luck completed 21 of 38 passes for 228 yards and no turnovers.
"This is a game we need to learn from," Manning said. "We, I guess, had four turnovers and still somehow had a chance to win that game. I would have liked to have seen it go to a two-point game down there toward the end and see what would have happened, but it never quite got to that point.
"You can go back to different parts of the game and we got behind, mistakes there, but we still had a chance there at the end. We certainly have to improve from this game because we weren't as sharp execution-wise as we'd like to be."
After an emotional week when Colts owner Jim Irsay made some questionable comments that appeared ungrateful of all that Manning had done for the franchise, Manning was honored with a video tribute.
Manning thanked the fans, who gave him a standing ovation.
"Hopefully we'll have a chance to play these guys again because that would mean we made the playoffs," Manning said. "I think if there is a next time it may be a little bit easier just because it was somewhat of an emotional week and it can be a little bit draining, I will say that."
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Aaron Wilson covers the Ravens for The Baltimore Sun.