Indianapolis Colts defensive tackle Fili Moala, who sprained his right ACL in the third quarter of Sunday's game against the Buffalo Bills, and is out for season.
Colts interim coach Bruce Arians made the announcement on Monday.
"Obviously it's a blow because Fili was playing extremely well for us," Arians told reporters during his weekly press conference. "We'll pick up the pieces and go on with the defensive line. We've had so many injuries there this year that we've built some depth. We'll just continue on with the guys that we have at that position."
Arians said that Clifton Geathers, Lawrence Guy and Ricardo Mathews will fill in.