Colts 27, 49ers 7

Eric Gilmore, The Sports Xchange
The SportsXchange

SAN FRANCISCO -- Quarterback Andrew Luck passed for 164 yards ran for a touchdown, lifting the Indianapolis Colts to a 27-7 victory Sunday over the San Francisco 49ers at Candlestick Park.
Luck faced his former Stanford coach, Jim Harbaugh, for the first time in the NFL, and played in the Bay Area for the first time as a pro. Luck completed 18 of 27 passes and had a passer rating of 82.9.
Colts starting running back Ahmad Bradshaw carried 19 times for 95 yards and a touchdown
Running back Trent Richardson, who came to Indianapolis from Cleveland on Wednesday night in a trade, scored a 1-yard touchdown on his first carry as Colt. For the game, he carried 13 times for 35 yards.
One week after passing for 127 yards -- his lowest career total as a starter -- in a 29-3 loss to Seattle, 49ers quarterback Colin Kaepernick threw for just 150 yards against the Colts. He completed 13 of 27 passes and lost a fumble deep in 49ers territory late in the fourth quarter and threw an interception. Kaepernick posted a passer rating of 49.9.
The Colts (2-1) outgained the 49ers (1-2) 336 yards to 254.
Niners outside linebacker Aldon Smith, who was arrested early Friday morning on suspicion of driving under the influence of alcohol, started the game and made five tackles.
The Colts extended their three-point halftime to 13-7 on Adam Vinatieri's 41-yard field goal with 6:46 left in the third quarter. The Colts marched 52 yards in 10 plays for the score as Luck scrambled for 15 yards on one key play and hit Reggie Wayne for 14 yards over the middle on another.
Late in the fourth quarter, the Colts marched 80 yards for Luck's 6-yard touchdown run on third-and-6. Luck faked a handoff to Bradshaw, who headed right, then ran around left end untouched and into the end zone with 4:13 left.
Luck's touchdown run gave the Colts a 20-7 lead. Then, after linebacker Jerrell Freeman forced and recovered a Kaepernick fumble at the 49ers' 8-yard line, the Colts capitalized with Bradshaw's 1-yard touchdown run to put Indianapolis up 27-7 with 2:58 left.
The Colts built a 10-7 halftime lead as Luck completed 12 of 17 passes for 94 yards and posted a passer rating of 83.8. Kaepernick struggled, completing just 2 of 8 pass for 38 yards and a rating of 46.9. The 49ers went three-and out on three of their first four drives and had only seven first downs in the opening half.
The Colts took the opening kickoff and marched 80 yards in seven plays for a touchdown, with Richardson scoring on a 1-yard run. The Colts used a pair of 49ers penalties -- unnecessary roughness on safety Donte Whitner and pass interference on cornerback Tarrell Brown -- to move to their 47.
Luck hit wide receiver Darius Heyward-Bey for 14 yards to the 39, then running Ahmad Bradshaw for six yards to the 33. Luck's 19-yard strike to Heyward-Bey gave the Colts first-and-goal from the 7. After Luck connected with tight end Coby Fleener for six yards, Richardson found a big hole over right guard and scored standing.
The 49ers pulled even with 4:13 left in the first quarter on Kendall Hunter's 13-yard touchdown run, capping a nine-play, 91-yard drive. Gore carried three times for 54 yards on the drive. Gore's 22-yard burst around right end gave the 49ers a first down at the Colts' 41. Two plays later, Gore went around right end again for 21 yards to the Colts' 10.
After losing three yards on a first down run, Hunter scored standing on a draw play.
Indianapolis took a 10-7 lead on Vinatieri's 43-yard field goal with 7:00 left in the first half.
NOTES: Niners inside linebacker Patrick Willis suffered a groin injury late in the third quarter and did not return to the game. ... San Francisco TE Vernon Davis (hamstring), who was injured last week against Seattle, was inactive Sunday. Rookie TE Vance McDonald started. ... Davis' injury scrapped an expected meeting with his younger brother, Colts CB Vontae Davis. They have never faced each other during their football careers at any level. ... Four injured Colts initially listed as starters were inactive: FS LaRon Landry (ankle), MLB Pat Angerer (knee), C Samson Satele (elbow) and TE Dwayne Allen (hip), who has been ruled out for the season. Kelvin Sheppard started for Angerer, DeLano Howell for Landry and Coby Fleener for Allen. ... The Colts shuffled their offensive line with right guard Mike McGlynn moving to center, and backup lineman Jeff Linkenbach starting at right guard. ... Niners S Bubba Ventrone, a special teams player, left the game early in the second quarter with a concussion. ... Colts DT Ricky Jean Francois left the game with a groin injury in the fourth quarter.