TUCSON, Ariz. -- The No. 5 ranked Oregon Ducks learned Saturday how the other 95 percent live.
Often a blowout inflictor, Oregon suffered its most lopsided defeat in more than five years when Arizona halfback Ka'Deem Carey rushed for 206 yards and four touchdowns in the Wildcats' 42-16 victory at Arizona Stadium.
"We've got magic out here," Carey said.
Carey, a junior, set school career records with 3,913 rushing yards and 49 touchdowns as the Wildcats (7-4, 4-4) broke a two-game losing streak. Carey, who has rushed for at least 100 yards in 14 straight games, also set a school game record with 48 carries.
"Whatever it took to get his victory," Carey said. "It's a together thing, and everything came together today."
Carey scored on 6-, 1-, 9- and 1-yard runs, and his last touchdown gave the 20-point underdog Wildcats a 35-9 lead with 7:07 remaining in the third quarter.
Oregon (9-2, 6-2) was eliminated from the Pac-12 North title chase and will not play in a BSC bowl game for the first time in five seasons.
The Ducks and No. 9 Stanford have two division losses apiece after the Cardinal beat California on Saturday. Stanford (9-2, 7-2) will win the division title even if the Oregon beats Oregon State next week by virtue of its 26-20 victory over the Ducks on Nov. 7.
The normally high-powered Ducks suffered their worst loss since a 44-10 defeat at Southern California on Oct. 4, 2008. They lost seven games by a total of 52 points from 2009-12.
"It's not fun being on this end of it," Oregon coach Mark Helfrich said. "Ka'Deem Carey was certainly as advertised."
Ducks quarterback Marcus Mariota threw for 308 yards and two touchdowns, and his 2-yard scoring pass to wide receiver Josh Huff closed the Ducks' deficit to 35-16 three plays in the fourth quarter.
Carey's fourth touchdown capped a 75-yard drive to put the game out reach with 8:59 remaining.
Arizona quarterback B.J. Denker passed for 178 yards and rushed for 102 more, throwing touchdown passes to wide receivers Nate Phillips and Terrence Miller as the Wildcats built a 28-9 halftime lead.
"Redemption," said Denker, whose team lost its two previous home games to UCLA and Washington State. "I'm just trying to get getter every week. I wanted to come out and prove to everyone that I could play football here and we could play football here against the best teams. We're a good team. We just dominated them in all three phases."
Oregon won the last five games in the series prior to Saturday, winning 49-0 in 2012 and scoring 56, 48, 44 and 55 in the previous four.
Oregon had 506 yards to Arizona's 482, but the Ducks committed the only three turnovers of the game and also failed on two fourth-down plays, one from the Arizona 6-yard line early in the third quarter of a 28-9 game.
"As far as execution and effort, this was without question the best we played all year," second-year Arizona coach Rich Rodriguez said.
Arizona had not beaten a higher ranked team since it stopped the then-No. 2 Ducks, 34-24, on Nov. 15, 2005.
"We had to leave this season with an upset. Let's leave history," Carey said.
"We've never been blown out like this before in my life," Mariota said. "We have to bounce back. We have to come back and fight."
Mariota, who has been bothered by a knee injury the last three weeks, said he suffered a head injury during the game, although he played the entire game.
Asked if it was a concussion, he said: "I'm not too sure. It hurts."
Mariota threw two interceptions in the game, including one on the first offensive play to break a string of 343 consecutive passes without one. He had not thrown a pick in 285 attempts this season.
Arizona linebacker Scooby Wright intercepted Mariota's first pass after Ducks' wide receiver Bralon Addison could not handle a perfect pass and cornerback Shaquille Richardson made an acrobatic save and flipped the ball to Wright stepping out of bounds. Carey scored on a 6-yard run nine plays later to cap that possession.
Denker's 9-yard scoring pass to Phillips after an Oregon three-and-out made it 14-0 with 7:09 left in the first half.
Mariota's 6-yard touchdown run on the next drive was negated by a holding penalty before Matt Wogan made a 33-yard field goal to make it 14-3.
Denker's 5-yard scoring pass to Miller capped an 83-yard drive with 11:39 remaining in the second quarter for a 21-3 lead, and Oregon never was closer than 12 points thereafter.
NOTES: Sophomore QB Marcus Mariota passed for a touchdown in all 24 of his games at Oregon. ... Arizona became one of seven Pac-12 teams with at least seven victories this season. The Pac-12 has seven bowl affiliations. ... Arizona finishes its season at arch-rival Arizona State in the Territorial Cup game next Saturday. ... Ducks sophomore RB Byron Marshall, who needed nine yards to post the 20th 1,000-yard rushing season in school history, got just 4 yards on Saturday after leaving early with an undisclosed injury.