The Cardinals look for a third straight victory while trying to send the Rockies to a seventh consecutive defeat Monday night at Coors Field.
St. Louis (41-35) followed a three-game skid in which it totaled four runs by scoring nine to win the final two against Philadelphia, concluding a 7-3 homestand.
"We're in grind mode and we've been that way here for a while," manager Mike Matheny told the Cardinals' official website after Sunday's 5-3 victory.
"I don't see it going away any time soon. That's the kind of season we're in. Every game is just a knock-down, drag-out. None of them are going to be easy. I think that's just the season we're set up for."
The Cardinals are playing well heading into their matchup with Colorado (34-41), which has allowed the Los Angeles Dodgers and Milwaukee to hit .324 and score 46 runs during its six-game slide.
"We just have to keep fighting, keep fighting for wins,'' said Rockies manager Walt Weiss, whose team has dropped 21 of 29 overall and 11 of 14 at home.
Ex-Rockies outfielder Matt Holliday has batted .211 in his last 10 road games for St. Louis, but .429 with seven home runs and 20 RBIs in 14 contests at Coors Field since he was acquired by the Cardinals in 2009.
Teammate Lance Lynn (7-5, 3.15 ERA) is 1-0 with a 1.96 ERA in three starts against the Rockies. He's posted a 2.92 ERA in his two starts at Colorado, not getting a decision in the pair of losses.
Lynn is 0-3 with a 3.86 ERA in his past four road starts since posting a 2.04 ERA to win his first three away from home in 2014.
The right-hander has given up two or fewer runs in six of his last seven starts. He allowed two in six innings of a 3-2 loss to the New York Mets on Wednesday.
Troy Tulowitzki is 1 for 3 with a double against Lynn.
Though he's batting a major league-high .360, Tulowitzki has gone 8 for 41 (.195) with 12 strikeouts in his last 11 games against the Cardinals. He does have nine RBIs during that span.
Colorado's Jhoulys Chacin (1-5, 4.53) has gone 1-1 with a 2.84 ERA in his past three starts. He allowed three runs on a pair of homers in six innings of a 4-2 road loss to the Los Angeles Dodgers on Tuesday.
Despite the home runs, Chacin remains confident.
"My sinker is working," he told the Rockies' official website. "I can throw my sinker down and away. I can throw my sinker down and in, and I can control it."
The right-hander hasn't had any success against St. Louis, however, going 0-2 with a 6.43 ERA in three games - two starts.
Holliday is 2 for 5 with a home run off of Chacin, while Allen Craig is 3 for 5 with a triple.
Craig is 8 for 17 with six RBIs in six games at Coors Field.