Borussia Dortmund only needs a single point from its trip to the Volkswagen Arena to face Wolfsburg in order to secure the runner-up position in the Bundesliga.
However, with one eye on the Champions League final against domestic rival Bayern Munich later this month, Jurgen Klopp may well rotate his squad for the fixture.
Felipe Santana will remain at the heart of defense but will this time feature alongside Mats Hummels rather than Neven Subotic, who played the 1-1 draw with the Bavarian giants last weekend.
Youngsters Leonardo Bittencourt and Moritz Leitner will be given rare starts, while Marco Reus replacing Robert Lewandowski gives Julian Schieber the chance to lead the line. Mario Gotze is unlikely to feature until the final due to injury.
Wolfsburg is only expected to make one change after sharing the spoils with Hamburg last week, as Simon Kjaer begins ahead of Robin Knoche at center back.