DENVER - Peyton Manning threw three of his four touchdown passes in the third quarter to break a close game wide open, and the Denver Broncos went on to beat the Philadelphia Eagles 52-20 Sunday for their club record 15th straight regular season win dating to last year.
Trindon Holliday returned a kick 105 yards for a touchdown and linebacker Steven Johnson blocked a punt and returned it 17 yards for another score as the Broncos also broke a 50-year-old team record for points in a game. Their previous high was 50 against San Diego on Oct. 6, 1963.
Demaryius Thomas and Wes Welker each caught two touchdown passes from Manning, who had four touchdown passes in a game for the 24th time in his career, an NFL record. He has 16 touchdown passes in four games without throwing an interception, matching the NFL mark set by Milt Plum in 1960.
Manning completed 28 of 34 passes for 327 yards before giving way to understudy Brock Osweiler early in the fourth quarter. Manning was watching from the sideline when Matt Prater kicked a 53-yard field goal for the Broncos' record-setting point total.
It was still shy of the most points the Eagles have ever allowed, 62 to the New York Giants, in 1972.
Michael Vick completed 14 of 27 throws for 248 yards. He also ran for 41 as the Eagles fell to 1-3. Nick Foles had a fourth-quarter scoring pass of 6 yards to Jeff Maehl after the game was out of reach.
The Broncos led by eight at the break, then scored 21 third-quarter points on Manning's touchdown passes of 1 yard and 15 yards to Thomas and 4 yards to Welker.
Johnson then burst up the middle to block Donnie Jones' punt, scooping up the loose ball and going in for the score.
The Broncos, who closed last season by winning 11 straight before losing to Baltimore in the playoffs, bolted to a 14-3 first-quarter lead behind Holliday's third regular season kick return for a touchdown, a Broncos team record, and led 21-13 lead at the break after Knowshon Moreno capped a long drive with a 4-yard touchdown run with 5:05 left in the second quarter.
Manning took the Broncos 74 yards on their opening possession, finishing off the break-neck, no-huddle drive with a 6-yard scoring pass to Welker.
The Eagles settled for a 35-yard field goal by Alex Henery for their first score after Brent Celek dropped a third-down pass by Vick.
The Broncos answered even before their quick-strike offense could get its hands on the ball. Sprung by blocks from David Bruton and Joel Dreessen, Holliday broke through for his third regular season kick return for a touchdown, a Broncos team record, that put Denver up 14-3.
Holliday dodged a diving Henery at midfield and sprinted into the clear, going untouched along the left sideline to tie his own team record for the longest kick return in team history.
The Eagles scored the next 10 points, pulling to within a point of the Broncos on Henery's second field goal, a 25-yarder, and Chris Polk's 4-yard touchdown run. But that proved to be as close as the Eagles could get.
NOTES: Tom Nalen, a five-time Pro Bowl center and a member of the Broncos' Super Bowl winning teams in 1997 and '98, was formally inducted into the team's Ring of Fame during halftime ceremonies. ... Welker becomes first Broncos players since Al Denson in 1969 with at least one touchdown pass in each of his first four games of the season. ... The Eagles came in with the league's second leading offense, behind the Broncos. Last regular season loss for Broncos came on Oct. 7, 2012, 31-21, at New England.