DENVER -- Peyton Manning tied the NFL record with seven touchdown passes, including three in the third quarter to break open a tight game, and the Denver Broncos pulled away to beat the defending Super Bowl champion Baltimore Ravens 49-27 Thursday night in the NFL's season-opening showcase.
Third-year tight end Julius Thomas, shaking off an arrest last week for missing a court hearing on a traffic citation, and free agent addition Wes Welker, atoning for a muffed punt, each caught two of Manning's scoring passes to help ease some of the sting from Broncos' double-overtime playoff loss to the Ravens in January.
Demaryius Thomas also had two touchdown catches, including the longest of the night, 78 yards.
Manning, a four-time MVP who is starting his second season with Denver after playing the bulk of his career with the Indianapolis Colts, completed 27 of 42 for 462 yards. His previous high was six touchdown passes in a game, which he accomplished twice, most recently against the Detroit Lions on Nov. 25, 2004.
Joe Flacco, whose brilliant play keyed the Ravens' championship run last season and won him a new lucrative contract, completed 34 of 62 for 362 yards but faced withering defensive pressure after the Broncos gained a commanding lead with a 21-point third quarter.
Flacco was intercepted twice, though he was spared from having the second returned for a touchdown when Broncos linebacker Danny Trevathan, celebrating prematurely, simply let the ball drop a yard before he reached the goal line and it rolled out of the back of the end zone for a touchback. That returned possession to the Ravens at the 20.
The Ravens lost key elements of their offense when wide receiver Jacoby Jones and right tackle Michael Oher both left the game in the second quarter because of injury.
Oher went out with an ankle sprain, and Jones suffered a knee sprain when rookie Brynden Trawick collided with his teammate as Jones prepared to field a punt.
Denver was without pass-rushing star Von Miller, who began serving a league-imposed six-game suspension for violating the NFL's substance-abuse policy.
Baltimore led 17-14 at halftime. The Broncos took their first lead when Manning capped the opening drive of the third quarter with a 28-yard scoring pass to Andre Caldwell.
In quick succession, the Broncos' David Bruton blocked Sam Koch's punt, leading two plays later to Manning's 5-yard TD pass to Welker. After Denver's defense forced another punt, Manning drove the Broncos to another score, finishing with a 2-yard TD pass to Welker. Suddenly, Denver was up 35-17.
Manning's sixth touchdown pass was a 26-yarder to Demaryius Thomas with 13:19 left to play.
After the Trevathan blunder, Flacco drove the Ravens to a touchdown, finishing with a 13-yard scoring pass to Marlon Brown. Baltimore added a field goal to pull within 42-27, but there was no keeping up with Manning.
Manning punctuated his performance with the 78-yarder to Demaryius Thomas late in the fourth quarter.
The Ravens were on top at the break thanks to Justin Tucker's tiebreaking, 25-yard field goal with seven seconds left in the second quarter. Baltimore failed to convert a first-and-goal at the 6-yard line into a touchdown.
Cornerback Kayvon Webster tipped away a first-down pass intended for Brandon Stokley, a second-down run went nowhere, and Ravens tight end Dallas Clark dropped a third-down pass with a clear path to the end zone.
The Ravens struck first, scoring the game's first touchdown on Flacco's 2-yard pass to fullback Vontae Leach.
But the Broncos came back to tie it on Manning's first touchdown pass to Julius Thomas, which was set up by Chris Harris' leaping interception of a pass Flacco over the middle intended for Stokley.
The pick ended a string of 210 consecutive passes by Flacco without an interception dating back to last Dec. 16, when Harris also swiped a Flacco pass and returned it for a touchdown in Denver's 34-17 regular-season win over Baltimore.
Welker's ill-advised attempt to field a punt inside the Broncos' 5-yard line led to a muff that the Ravens recovered, leading to Rice's 1-yard touchdown run on the next play and a 14-7 Ravens lead.
Again, Manning turned to his young tight end. With the Broncos operating the no-huddle offense, Manning and Julius Thomas hooked up for a 44-yard catch and run to the Ravens' 23. The Broncos went the rest of the way on the next play with Manning hitting Julius Thomas along the left sideline for the score.
NOTES: The other quarterbacks to throw seven touchdown passes in a game were the Chicago Bears' Sid Luckman in 1943, the Philadelphia Eagles' Adrian Burk in 1954, the Houston Oilers' George Blanda in 1961, the New York Giants' Y.A. Tittle in 1962 and the Minnesota Vikings' Joe Kapp in 1969. ... The game was delayed 33 minutes at the start because of lightning in the area. ... Manning has thrown at least one touchdown pass in 26 consecutive games, including playoffs. ... Julius Thomas became the first tight end and fifth Broncos player overall with multiple touchdown catches in a season opener. ... A second-quarter pass initially ruled a completion by Demaryius Thomas was challenged by Ravens coach John Harbaugh and overturned when replay review showed the ball hit the ground. ... The Ravens' inactive players included DTs Arthur Jones and Brandon Williams. ... CB Champ Bailey was listed among the Broncos' inactive players.