DENVER -- Knowshon Moreno ran for three touchdowns, Peyton Manning threw for two scores to help offset three turnovers and the Denver Broncos pulled away to beat the winless Jacksonville Jaguars 35-19 on Sunday.
Manning had touchdown passes of 3 yards to Julius Thomas and 20 yards to Wes Welker to increase his season total to 22, the most through six games in NFL history. But he also threw an interception that was returned for a touchdown and fumbled twice.
Moreno ran for 42 yards and had touchdowns of 3, 8 and 5 yards, all in the second half, to help Denver (6-0) extend its franchise-record winning streak to 17 regular-season games.
Denver also was bolstered by the return of 12-time Pro Bowl cornerback Champ Bailey, who made his season debut after missing the first five games with a foot sprain suffered in a preseason game against Seattle.
But it was tougher against Jacksonville than the oddsmakers, who made Denver a 27-point favorite going into the game, thought it would be. The Broncos were held to a season low in points.
Jacksonville tried hard for the upset from the get-go, starting with a fake punt on a fourth-and-4 from its own 26-yard line in the opening minutes of the game. The Broncos stuffed fullback Will Ta'ufo'ou well short of the first down after he took the direct snap, giving Denver a short field for its first score.
Chad Henne, starting in place of injured Jaguars quarterback Blaine Gabbert (hamstring), completed 27 of 42 passes for 303 yards. He was intercepted two times.
Justin Blackmon added 14 receptions for 190 yards for Jacksonville (0-6).
Up by two points at the half, the Broncos got two third-quarter touchdown runs from Moreno around a scoring run by Jacksonville's Maurice Jones-Drew to make it 28-19.
Manning later fumbled a shotgun snap that was recovered by Jaguars cornerback Mike Harris, but Jacksonville failed to capitalize. Kayvon Webster intercepted a pass by Henne, and Manning guided the Broncos down the field, leading to Moreno's third touchdown run with 9:09 remaining in the fourth quarter.
Denver pulled out to a 14-0 lead as Manning finished the Broncos' opening possession with a short scoring pass to Thomas before hitting Welker for a 20-yard TD pass.
It was the 800th career reception by Welker, who became the 27th player in NFL history to reach the milestone.
Taking advantage of a fumbled snap by Manning, Jacksonville added a second field goal by Josh Scobee, a 30-yarder, to make it 14-6. Scobee also kicked a 50-yarder earlier.
In the second quarter after a botched hold on a Jaguars field goal try, the Broncos took over on their 42, but Manning underthrew a third-down pass intended for Welker. Linebacker Paul Posluszny reached up to make the interception and returned it 59 yards for a touchdown, pulling the Jaguars to 14-12 at halftime.
Jacksonville had a chance to tie it with a two-point conversion, but Henne's pass was picked off in the end zone by Bailey.
NOTES: Jaguars WR Cecil Shorts III left in the first quarter with a shoulder sprain and did not return. ... Rockies great Todd Helton, a friend and former college teammate of Manning who retired after 17 seasons, was an honorary captain for the Broncos during the pregame coin flip. ... Welker is only the second undrafted player with at least 800 career receptions. Rod Smith, a member of the Broncos' Ring of Fame, is the other. ... Scobee has made 29 consecutive field goals in October. He hasn't had a miss during the month since Oct. 18, 2009. ... Broncos RT Orland Franklin left the game with a left knee injury. ... The loss snapped Jacksonville's three-game winning streak against Denver.