KANSAS CITY, Mo. -- The Toronto Blue Jays won, defeating the Kansas City Royals 8-4, but the Friday night victory could be extremely costly with an injury to Jose Reyes.

Reyes, who is hitting .429 in a nine-game hitting streak, had to be carted off the field in the sixth inning with a sprained left ankle and was taken to a hospital for a MRI.

Reyes greeted reliever Luke Hochevar with a two-run single and swiped second base, his Major League-leading fifth stolen base, but he injured his leg while sliding and was in extreme pain.

Reyes slid late into the bag and his left ankle rolled under him in the cumbersome slide. He rotated onto his back and was yelling in pain before pulling his uniform top over his face. He was lifted into a cart and taken out through the Blue Jays' bullpen in right-field.

Reyes, a four-time National League All-Star with the New York Mets, was acquired in a blockbuster trade in November with the Miami Marlins. He was hitting .395 and had reached base in all 10 games this season, failing to get a hit only in the season opener.

Reyes' injury damped J.A. Happ picking up his second victory of the season. Happ, who threw 41 of his 110 pitches in the Royals' three-run first, lasted five innings, allowing four runs on five hits, while walking three and striking out four. Happ (2-0) is the only Blue Jays starter with a win this season. Aaron Loup worked three perfect innings to log his first big league save.

Luis Mendoza took the loss, charged with eight runs, seven earned, on seven hits and three walks in 5 2/3 innings.

Emilo Bonifacio led the Blue Jays' offense with two double and two RBIs.

The Blue Jays scored five runs in the first three innings to seize an early lead.

J.P. Arencibia singled home Melky Cabrera with the first run. Adam Lind's run-producing double to right made it 2-0, bringing home Edwin Encarnacion, who had walked.

Lorenzo Cain contributed a two-run single, while Salvador Perez singled home Alex Gordon with the first run.

The Jays regained the lead in the second with the help of the Royals. Colby Rasmus, who extended his hitting streak to seven games, and Bonifacio led off the inning with back-to-back doubles. Bonifacio took third on the throw home and scored on catcher Perez's throwing error.

Mike Moustakas' throwing error in the third gifted the Blue Jays with another run. Encarnacion, who reached on the error, scored on Adam Lind's sacrifice fly. After not committing an error in their first seven games, the Royals made three errors in the first three innings.

Happ settled down after the first, retiring the next 10 batters before Elliot Johnson led off the fifth with a bunt single. Johnson stole second and scored on Alcides Escobar's double, cutting the Blue Jays' lead to 5-4.

NOTES: OF Casper Wells, who the Blue Jays claimed off waivers from the Mariners, was in uniform Friday. To make roster room for Wells, the Blue Jays optioned RHP Edgar Gonzalez to Class AAA Buffalo. ... Left-handed hitting 1B Eric Hosmer, who went 2-for-11 with one RBI in the series against the Twins, and 2B Chris Getz, who had one single in 10 at-bats in the same series, were held out of the lineup against Happ. Miguel Tejada started at first base and Johnson started at second base. ... A premier pitching matchup is on tap Saturday with National League 2012 Cy Young Award winner RHP R.A. Dickey starting for the Blue Jays, while the Royals will counter with RHP James Shields, who has a career 3.13 ERA in April and 11 career victories against Toronto.