TORONTO -- J.P. Arencibia led a five-homer barrage with a pair of home runs as the Toronto Blue Jays' defeated the Cleveland Indians 10-8 on Thursday for their first win of the season.
The Blue Jays (1-2) who lost their first two games to the Indians (2-1) also received home runs by Jose Bautista, Edwin Encarnacion and Colby Rasmus before a crowd of 19,515 at Rogers Centre.
Toronto left-hander Mark Buehrle could not stand prosperity, squandering two-run and three-run leads. He lasted 5 1/3 innings, allowing seven hits that included home runs by Carlos Santana and Mark Reynolds and six runs. He also allowed a walk and hit two batters.
Steve Delabar (1-0) finished the sixth inning to pick up the win and Casey Janssen pitched the ninth for the save.
Arencibia led off Toronto's three-run sixth with his second homer of the game on a 1-1 fastball to put Toronto into 7-6 lead and chase Cleveland starter Brett Myers (0-1) who gave up four home runs among his seven hits.
Cody Allen replaced Myers and after retiring the first batter gave up a home run to Rasmus on a 3-1 fastball. The Blue Jays weren't done with Allen as Emilio Bonifacio hustled a double and scored on an error by Reynolds who was playing first base.
Toronto built a 6-3 lead on three home runs through five innings, but Cleveland came back against an ineffective Buehrle in the top of sixth.
A leadoff walk, a hit batter and doubles by Santana and Lonnie Chisenhall tied the game.
Left-hander Aaron Loup got two outs in the seventh but allowed two singles and was charged with a run when right-hander Esmil Rogers allowed a single to Reynolds.
Left-hander Darren Oliver allowed a run in the eighth on two-out doubles by Asdrubal Cabrera and Jason Kipnis.
The Indians loaded the bases on a walk and an infield hit but Santana was retired to end the inning on a fine play and long throw by second baseman Bonifacio on a grounder up the middle.
The Blue Jays tacked on a run in the eighth against Matt Albers after one-out walks to Jose Reyes and Melky Cabrera. Bautista's grounder up the middle resulted in a force at second but Cleveland could not complete the double play as Reyes came around to score.
Rajai Davis took over in right field for Bautista in the ninth.
The Indians scored in the first on consecutive two-out doubles by Jason Kipnis and Nick Swisher.
But Toronto's response was quick. Reyes led off the bottom of the first with a walk and one out later Bautista hit his second homer of the season on a 1-0 slider. Arencibia hit his first homer of the season on the first pitch of the second inning, a fastball, to give the Blue Jays a 3-1 lead.
Cleveland tied it on successive two-out home runs by Santana, his first, on a 3-1 fastball, and Reynolds, his second, on a 2-2 change-up. Reynolds won Wednesday's game with an 11th-inning homer, his first hit of the season.
Encarnacion's first homer of the season, a laser to left on a 2-0 fastball, put Toronto into a 6-3 lead in the fifth. It scored Reyes who singled with one out and Melky Cabrera who walked. Reyes was shaken up stealing second during Cabrera's plate appearance but after being attended to he was able to continue.
NOTES: Cleveland put left-hander Scott Kazmir on the disabled list Thursday with a strained right rib cage. Right-hander Trevor Bauer is expected to start Saturday against the Tampa Bay Rays in Kazmir's place. Kazmir will likely miss two or three starts. ... Both teams switched first basemen and designated hitters for Thursday's game. Swisher was at DH with Reynolds at first base for Cleveland and Adam Lind was at first base and Encarnacion at DH for Toronto. ... The Blue Jays open a three-game series at Rogers Centre on Friday against the Boston Red Sox who are managed by John Farrell, the manager at Toronto the previous two seasons. ... Mark DeRosa, who was making his first start of the season for Toronto, also will get the start at third base Friday when Boston starts left-hander Felix Doubront. DeRosa was used as a pinch-hitter in Wednesday's 3-2 loss in 11 innings. DeRosa will get the start at third base on Friday against Boston left-hander Felix Doubront. ... The Blue Jays will start right-hander Josh Johnson against the Red Sox on Friday.