Griffin suffered the quad injury during Friday night's 94-84 victory against the Los Angeles Lakers. He underwent an MRI on Saturday morning that revealed the injury.
Griffin will be re-evaluated in two weeks, and it's uncertain when he will return to action.
"Tough break," Clippers coach Doc Rivers told Yahoo Sports. "Blake was playing so well. We just have to keep pushing forward until his return."
Griffin is averaging 23.2 points, 8.7 rebounds and five assists in 30 games this season for Los Angeles. The five-time All-Star was third among Western Conference forwards in the first returns of All-Star balloting on Friday.
Reserve forwards Josh Smith, Paul Pierce and Wesley Johnson are candidates to replace Griffin in the Clippers' starting lineup. Los Angeles entered Saturday with the West's fourth-best record at 17-13.