Buffalo Bills coach Chan Gailey said on his weekly radio show that running back Fred Jackson will miss at least two to three weeks with a leg injury, ESPN.com reported Monday.
Jackson was injured in the fourth quarter of the Bills' 15-12 home loss to the St. Louis Rams on Sunday when he was tackled by two defenders.
With the Bills at 5-8 and not likely to make the playoffs, Jackson's season is probably over.
"It's not good," Gailey said via the team's website. "It's a minimum of two to three weeks. That's what I was told. Something could change this morning and it could be a better prognosis, but I was told it looks like it'll be a two- or three-week deal."
Jackson missed two games earlier this year with a sprained right knee.