The Golden Griffins (20-10, 14-5 Metro Atlantic Athletic Conference) built a 36-21 halftime advantage and led by no less than nine in the second.
Canisius reached 20 wins for the eighth time in program history and for the first time in back-to-back seasons since 1994-95.
The Griffins also moved into a three-way tie for second place in the conference with Quinnipiac and Manhattan. Canisius will visit Manhattan on March 2.
Jimmie Taylor and Anthony Myles had 15 points apiece for Rider (13-15, 9-10) which trailed after the opening minutes. Tommy Pereira had 11 points and Zedric Sadler scored 10.