The Spain Under-21 star, who has found first-team opportunities more forthcoming in recent weeks due to injuries to his defensive colleagues, did not travel with the squad to Russia for Tuesday's clash with Spartak Moscow.
And he could miss up to six matches as the Blaugrana look to confirm their place in the latter stages of the Champions League and maintain their unbeaten record in La Liga.
The 21-year-old, who made his debut for the Catalans in 2009-10, has played in four league games so far this season and seven in all competitions.
Barcelona and Spartak Moscow kick off in the Russian capital on Tuesday at noon eastern time. Tito Vilanova's side travels to Valencia to face Levante on Sunday.