Hernandez has a chance to top that run in Wednesday night's rematch but will have to cool off C.J. Wilson and the surging Angels for that season-high fourth consecutive victory.
Hernandez (6-1, 2.75 ERA) gave up three runs in his first three innings in the opener March 31 before tossing three consecutive scoreless innings. The Mariners rallied to take the lead in the seventh, and he finished with 11 strikeouts to claim a 10-3 victory.
The right-hander has gotten a combined 21 runs from his teammates in his last three outings but has also helped himself lately with a 1.69 ERA in his past two. He gave up one run over eight innings and struck out nine Friday in a 6-1 win against Houston.
Hernandez is 2-1 with a 1.88 ERA in his last four starts against the Angels (29-22) and has totaled 31 strikeouts in his past three.
Wilson (6-3, 3.00), though, enters this start having given up one run and nine hits over 15 1-3 innings in back-to-back wins. The left-hander allowed that lone run over his 6 1-3 innings Friday in a 6-1 win over Kansas City.
Wilson wasn't nearly as dominant in his only start against Seattle (25-26) this season. He was tagged for six runs over 5 2-3 innings in an 8-3 defeat April 1, his second loss in as many matchups.
Wilson is 5-1 with a 2.03 ERA in his last six starts at Safeco Field, with the most recent a 6-3 victory April 26, 2013.
He'll likely have to face a red-hot Robinson Cano in this outing. The second baseman is batting .435 with 12 RBIs in his last 16 games and went 2 for 5 with a run-scoring single in the ninth inning Tuesday for his seventh multihit game in his last nine contests.
The Mariners, though, never led in a 6-4 defeat, their third in the last four games. Justin Smoak had a solo homer - his first since May 12 - and manager Lloyd McClendon sees signs the first baseman will break out of his 4 for 28 slump soon.
"He's starting to pick it up again," McClendon told the team's official website. "His at-bats are starting to get better again, particularly for the left side. He made some adjustments with (hitting coach Howard Johnson) and I think we're going to see some good things from him."
Smoak is 8 for 32 with three homers lifetime versus Wilson.
Los Angeles, meanwhile, has won 13 of 18 overall and six of eight on the road. Chris Iannetta went 2 for 3 with an RBI double in Tuesday's win and is batting .391 with two homers in his past eight games.
The Angels, though, might have lost reliever Sean Burnett for the foreseeable future because of problems with his surgically repaired left elbow.
"He just felt something in his elbow," manager Mike Scioscia said. "We don't know exactly what, he'll be going back down to Southern California (Wednesday) to be evaluated. It looks like disabled list, but we'll see what's going on."
Iannetta is 2 for 17 with five strikeouts lifetime versus Hernandez. Mike Trout, seeking to extend an eight-game hit streak, has fared much better, going 16 for 41 (.390) with a pair of homers.
Cano, batting .383 in his last 28 games against the Angels, is 14 for 37 against Wilson in his career, including the postseason.