CINCINNATI -- Angels catcher Chris Iannetta hit a solo home run in the third inning for the game's first run, then approximately three hours later, his bases-loaded hit in the 13th inning drove home the go-ahead runs, lifting Los Angeles to a 3-1 victory over the Cincinnati Reds.

Iannetta's clutch hit came on a 3-2 pitch from Reds right-hander J.J Hoover (0-1) and helped end a four-hour, 45-minute Opening Day marathon before 43,168 fans at Great American Ball Park, most of whom weren't around for the finish.

Two walks and a hit batter loaded the bases for Iannetta with two outs in the 13th, and the catcher singled to left field to score Josh Hamilton and Howie Kendrick.

Shin-Soo Choo went 2-for-5 with a double and scored a run in his Reds debut. He had two of just three hits managed by Cincinnati. The Angels committed three errors but the Reds, couldn't take advantage.

After Choo's leadoff single in the eighth, the Angels bullpen held Cincinnati hitless through the next five innings. Mark Lowe (1-0) earned the victory, and Ernesto Frieri picked up the save.

Monday's game-time temperature was 47 degrees with a brisk breeze, and starting pitchers Johnny Cueto of Cincinnati and Jered Weaver of Los Angeles made it a tough afternoon for hitters.

Weaver allowed one run and two hits over six innings, striking out four. Iannetta's homer was one of just three hits allowed by Cueto, who struck out nine in seven innings.

In the third inning, Reds left fielder Ryan Ludwick dislocated his right shoulder while sliding into third base. He is expected to undergo an MRI exam Tuesday to determine the extent of the injury.

Cueto, making his first start since suffering a strained oblique in the first inning of Game 1 of last year's NL Division Series, retired the first seven batters he faced Monday.

Iannetta, who hit just nine homers last season, belted an 0-1 pitch from Cueto into the left-center-field seats, putting the Angels ahead 1-0 in the third.

Choo led off the third with a double, reached third on Brandon Phillips' groundout and scored on a wild pitch, sliding in just ahead of Weaver's tag to tie the score 1-1. Ludwick reached third base on the play but injured his right shoulder during his slide. Chris Heisey replaced Ludwick.

NOTES: Monday's game was the first Opening Day matchup of interleague opponents in major league history. .. Hamilton went 0-for-4 with two walks in his Angels debut. ... Kendrick made his seventh straight Opening Day start, passing Bobby Knoop for most consecutive Opening Day starts by an Angels second baseman. .. Veteran Reds infielder Cesar Izturis made the club after batting .387 with five doubles and seven RBI this spring. Manager Dusty Baker said the 11-year veteran earned the nod due to his sure-handedness and experience. Izturis came off the bench Monday and went 0-for-2. .. The Reds demoted right-hander Logan Ondrusek to Double-A Pensacola due to his familiarity with Wahoos pitching coach Tom Brown.