| | P | Traded (The Kansas City Royals traded LHP Anthony Misiewicz to the St. Louis Cardinals.) To |
| | P | Designated for Assignment (The Kansas City Royals designated LHP Anthony Misiewicz for assignment.) |
| | 2B | Signed (The Kansas City Royals signed INF Ryan Goins to a minor league contract.) |
| | P | Signed (The Kansas City Royals signed RHP Zack Greinke.) |
| | 3B | Non-roster Invitee (The Kansas City Royals signed INF Matt Duffy to a minor league contract with an invitation to spring training.) |
| | C | Signed (The Kansas City Royals signed C José Briceño to a minor league contract.) |
| | C | Signed (The Kansas City Royals signed C José Briceño to a minor league contract.) |
| | P | Traded (The Boston Red Sox traded LHP Josh Taylor to the Kansas City Royals.) From |
| | P | Signed (The Kansas City Royals signed RHP Will McAffer to a minor league contract.) |
| | SS | Traded (The Kansas City Royals traded INF Adalberto Mondesi to the Boston Red Sox.) To |
| | P | Traded (The Minnesota Twins traded LHP Evan Sisk to the Kansas City Royals.) From |
| | P | Traded (The Minnesota Twins traded RHP Steven Cruz to the Kansas City Royals.) From |
| | CF | Traded (The Kansas City Royals traded OF Michael A. Taylor to the Minnesota Twins.) To |
| | P | Signed (The Kansas City Royals signed RHP Taylor Bloye to a minor league contract.) |
| | 3B | Signed (The Kansas City Royals signed INF Johan Camargo to a minor league contract.) |
| | C | Signed (The Kansas City Royals signed C José Briceño to a minor league contract.) |
| | 1B | Designated for Assignment (Signed) |
| | P | Signed as Free Agent (two-year contract) |
| | P | Signed to a Minor League Contract (Signed) |
| | P | Signed to a Minor League Contract (Signed) |
| | P | Signed to a Minor League Contract (Signed) |
| | P | Traded (for RHP Jake Wallace) To |
| | P | Signed to a Minor League Contract (Signed) |
| | P | Designated for Assignment (Signed) |
| | P | Signed as Free Agent (one-year contract) |
| | C | Signed to a Minor League Contract (Signed) |
| | SS | Drafted Via Rule 5 (Minor-league phase) |
| | SS | Signed (avoids arbitration) |
| | P | Free Agent - No Contract Offer (non-tendered) |
| | P | Free Agent - No Contract Offer (non-tendered) |
| | C | Cleared Waivers and Became a Free Agent (Signed) |
| | LF | Acquired Off Waivers (Signed) To |
| | C | Released (Signed) |
| | CF | Purchased From Minors (Signed) |
| | C | Purchased From Minors (Signed) |
| | P | Purchased From Minors (Signed) |
| | LF | Designated for Assignment (Signed) |
| | P | Designated for Assignment (Signed) |
| | P | Designated for Assignment (Signed) |
| | 1B | Signed (avoids arbitration) |
| | C | Declared Free Agency (Signed) |
| | C | Declared Free Agency (Signed) |
| | 2B | Purchased From Minors (Signed) |
| | P | Declared Free Agency (Signed) |
| | P | Purchased From Minors (Signed) |
| | C | Designated for Assignment (Signed) |
| | C | Declared Free Agency (C Jose Briceño declared free agency.) |
| | P | Acquired Off Waivers (Signed) To |
| | P | Declared Free Agency (Signed) |
| | P | Outrighted to Minors (Signed) |
| | P | Acquired Off Waivers (Signed) To |
| | P | Acquired Off Waivers (Signed) To |
| | P | Declared Free Agency (Signed) |
| | LF | Called Up from Minors (Signed) |
| | P | Called Up from Minors (Signed) |
| | SS | Called Up from Minors (Signed) |
| | P | Called Up from Minors (Signed) |
| | P | Called Up from Minors (Signed) |
| | 1B | Called Up from Minors (Signed) |
| | P | Called Up from Minors (Signed) |
| | P | Called Up from Minors (Signed) |
| | P | Called Up from Minors (Signed) |
| | P | Called Up from Minors (Signed) |
| | P | Called Up from Minors (Signed) |
| | P | Recalled From Minors Rehab (Signed) |
| | P | Sent to Minors (Signed) |
| | P | Recalled From Minors Rehab (Signed) |
| | P | Sent to Minors for Rehabilitation (Signed) |
| | P | Called Up from Minors (Signed) |
| | P | Sent to Minors (Signed) |
| | RF | Recalled From Minors Rehab (Signed) |
| | 1B | Sent to Minors (Signed) |
| | P | Sent to Minors for Rehabilitation (Signed) |
| | 1B | Removed From 10-Day IL (Right shoulder discomfort) |
| | 1B | Recalled From Minors Rehab (Signed) |
| | LF | Sent to Minors (Signed) |
| | P | Sent to Minors (Signed) |
| | P | Called Up from Minors (Signed) |
| | P | Sent to Minors (Signed) |
| | P | Outrighted to Minors (Signed) |
| | 1B | Sent to Minors for Rehabilitation (Signed) |
| | P | Called Up from Minors (Signed) |
| | P | Designated for Assignment (Signed) |
| | P | Purchased From Minors (Signed) |
| | 3B | Called Up from Minors (Signed) |
| | RF | Sent to Minors for Rehabilitation (Signed) |
| | C | Signed to a Minor League Contract (Signed) |
| | P | Reinstated From League Suspension (Signed) |
| | P | Called Up from Minors (Signed) |
| | P | Called Up from Minors (Signed) |
| | P | Sent to Minors (Signed) |
| | C | Called Up from Minors (Signed) |
| | 1B | Placed on 10-Day IL (Right shoulder discomfort) |
| | P | Called Up from Minors (Signed) |
| | P | Starting to Serve Suspension (Signed) |
| | 3B | Sent to Minors (Signed) |
| | LF | Called Up from Minors (Signed) |
| | P | Called Up from Minors (Signed) |
| | P | Sent to Minors (Signed) |
| | P | Acquired Off Waivers (Signed) To |
| | 3B | Reinstated from Paternity Leave List (Signed) |
| | SS | Sent to Minors (Signed) |
| | P | Designated for Assignment (Signed) |
| | P | Called Up from Minors (Signed) |
| | P | Sent to Minors (Signed) |
| | P | Reinstated from Bereavement/Family Medical Emergency List (Signed) |
| | SS | Signed to a Minor League Contract (Signed) |
| | SS | Called Up from Minors (Signed) |
| | 3B | Placed on Paternity Leave List (Signed) |
| | P | Suspension Announced By League (two games) |
| | P | Placed on Bereavement/Family Medical Emergency List (Signed) |
| | P | Called Up from Minors (Signed) |
| | C | Sent to Minors (Signed) |
| | LF | Called Up from Minors (Signed) |
| | P | Return of 27th man (Signed) |
| | P | Called Up from Minors (recalled as 27th roster player) |
| | P | Called Up from Minors (Signed) |
| | P | Released (Signed) |
| | RF | Transferred to 60-Day IL (Strained left quad) |
| | 3B | Purchased From Minors (Signed) |
| | SS | Sent to Minors (Signed) |
| | 2B | Purchased From Minors (Signed) |
| | C | Called Up from Minors (Signed) |
| | P | Transferred to 60-Day IL (Strained left knee) |
| | P | Sent to Minors (Signed) |
| | LF | Sent to Minors (Signed) |
| | 2B | Traded (for 2B Whit Merrifield, 3-player deal) From |
| | P | Traded (for 2B/OF Whit Merrifield, 3-player deal) From |
| | LF | Traded (for C Cam Gallagher) From |
| | 2B | Traded (for INF Samad Taylor & RHP Max Castillo) To |
| | C | Traded (for OF Brent Rooker) To |
| | P | Sent to Minors (Signed) |
| | P | Traded (for 3B Emmanuel Rivera) From |
| | P | Recalled From Minors Rehab (Signed) |
| | 3B | Traded (for RHP Luke Weaver) To |
| | P | Sent to Minors (Signed) |
| | 3B | NTR - Called Up From Minors (Signed) |
| | P | Sent to Minors (Signed) |
| | P | Traded (for cash considerations) From |
| | P | Called Up from Minors (Signed) |
| | P | Sent to Minors (Signed) |
| | P | Recalled From Minors Rehab (Signed) |
| | P | Sent to Minors (Signed) |
| | C | Removed From 10-Day IL (Torn ligament, left hand) |
| | C | Recalled From Minors Rehab (Signed) |
| | 3B | Sent to Minors (Signed) |
| | SS | Called Up from Minors (Signed) |
| | P | Traded (for OF Andrew Benintendi, 4-player deal) From |
| | LF | Traded (for LHP T.J. Sikkema, four-player deal) To |
| | P | Called Up from Minors (Signed) |
| | C | Sent to Minors for Rehabilitation (Signed) |
| | P | Called Up from Minors (Signed) |
| | P | Sent to Minors (Signed) |
| | P | Sent to Minors for Rehabilitation (Signed) |
| | P | Sent to Minors for Rehabilitation (Signed) |
| | RF | Placed on 10-Day IL (Strained left quad) |
| | 1B | Called Up from Minors (Signed) |
| | C | Reinstated From Restricted List (Signed) |
| | LF | Reinstated From Restricted List (Signed) |
| | P | Reinstated From Restricted List (Signed) |
| | P | Reinstated From Restricted List (Signed) |
| | CF | Reinstated From Restricted List (Signed) |
| | CF | Released (Signed) |
| | P | Reinstated From Restricted List (Signed) |
| | P | Released (Signed) |
| | 3B | Reinstated From Restricted List (Signed) |
| | C | Reinstated From Restricted List (Signed) |
| | LF | Reinstated From Restricted List (Signed) |
| | 1B | Sent to Minors (Signed) |
| | C | Sent to Minors (Signed) |
| | SS | Sent to Minors (Signed) |
| | 2B | Outrighted to Minors (return of Replacement Player) |
| | LF | Outrighted to Minors (return of Replacement Player) |
| | C | Outrighted to Minors (return of Replacement Player) |
| | 3B | Outrighted to Minors (return of Replacement Player) |
| | P | Sent to Minors (Signed) |
| | P | Called Up from Minors (Signed) |
| | P | Sent to Minors (Signed) |
| | 2B | Reinstated From Restricted List (Signed) |
| | P | Traded (for RHP Jonatan Bernal) To |
| | P | Called Up from Minors (Signed) |
| | P | Sent to Minors (Signed) |
| | P | Sent to Minors (return of Replacement Player) |
| | P | Recalled From Minors Rehab (Signed) |
| | P | Called Up from Minors (Signed) |
| | P | Called Up from Minors (recalled as Replacement Player) |
| | C | Called Up from Minors (Signed) |
| | SS | Called Up from Minors (Signed) |
| | 1B | Called Up from Minors (Signed) |
| | CF | Placed on Restricted List (COVID-19 protocol travel restrictions) |
| | P | Placed on Restricted List (COVID-19 protocol travel restrictions) |
| | 2B | Placed on Restricted List (COVID-19 protocol travel restrictions) |
| | C | Placed on Restricted List (COVID-19 protocol travel restrictions) |
| | 2B | Purchased From Minors (selected as Replacement Player) |
| | P | Placed on Restricted List (COVID-19 protocol travel restrictions) |
| | 3B | Purchased From Minors (selected as Replacement Player) |
| | LF | Placed on Restricted List (COVID-19 protocol travel restrictions) |
| | C | Placed on Restricted List (COVID-19 protocol travel restrictions) |
| | C | Purchased From Minors (selected as Replacement Player) |
| | 3B | Placed on Restricted List (COVID-19 protocol travel restrictions) |
| | P | Placed on Restricted List (COVID-19 protocol travel restrictions) |
| | LF | Called Up from Minors (selected as Replacement Player) |
| | LF | Placed on Restricted List (COVID-19 protocol travel restrictions) |
| | P | Return of 27th man (Signed) |
| | P | Recalled From Minors Rehab (Signed) |
| | P | Called Up from Minors (recalled as 27th roster player) |
| | LF | Sent to Minors (Signed) |
| | P | Designated for Assignment (Signed) |
| | LF | Traded (three-player deal for 2022 CB Pick #35) From |
| | P | Sent to Minors for Rehabilitation (Signed) |
| | P | Called Up from Minors (Signed) |