| | 1B | Sent to Minors (The Cleveland Guardians sent INF Kyle Manzardo to the minors.) |
| | P | Sent to Minors (The Cleveland Guardians optioned LHP Joey Cantillo to the minors.) |
| | LF | Sent to Minors (The Cleveland Guardians optioned OF Jhonkensy Noel to the minors.) |
| | 3B | Sent to Minors (The Cleveland Guardians optioned INF Juan Brito to the minors.) |
| | RF | Sent to Minors (The Cleveland Guardians optioned OF Johnathan Rodriguez to the minors.) |
| | P | Sent to Minors (The Cleveland Guardians optioned RHP Daniel Espino to the minors.) |
| | RF | Sent to Minors (The Cleveland Guardians optioned OF George Valera to the minors.) |
| | P | Non-roster Invitee (The Cleveland Guardians invited RHP Adam Oller to spring training.) |
| | P | Non-roster Invitee (The Cleveland Guardians invited RHP Jack Leftwich to spring training.) |
| | C | Non-roster Invitee (The Cleveland Guardians invited C Eric Rodriguez to spring training.) |
| | P | Non-roster Invitee (The Cleveland Guardians invited RHP Mason Hickman to spring training.) |
| | P | Non-roster Invitee (The Cleveland Guardians signed RHP Tyler Zuber to a minor league contract with an invitation to spring training.) |
| | C | Non-roster Invitee (The Cleveland Guardians signed C Dom Nuñez to a minor league contract with an invitation to spring training.) |
| | P | Non-roster Invitee (The Cleveland Guardians signed LHP Anthony Banda to a minor league contract with an invitation to spring training.) |
| | P | Signed (The Cleveland Guardians signed RHP Carlos Carrasco to a minor league contract with an invitation to spring training.) |
| | CF | Non-roster Invitee (The Cleveland Guardians signed OF Lorenzo Cedrola to a minor league contract with an invitation to spring training.) |
| | P | Released (The Cleveland Guardians released RHP Justin Lewis.) |
| | 1B | Non-roster Invitee (The Cleveland Guardians invited INF Kyle Manzardo to spring training.) |
| | CF | Non-roster Invitee (The Cleveland Guardians invited OF Petey Halpin to spring training.) |
| | P | Non-roster Invitee (The Cleveland Guardians invited RHP Tanner Burns to spring training.) |
| | C | Traded (The Cleveland Guardians traded C Christian Bethancourt to the Miami Marlins.) To |
| | C | Signed (The Cleveland Guardians signed C Austin Hedges.) |
| | P | Drafted Via Rule 5 (The Cleveland Guardians selected LHP John Doxakis in the Rule 5 Draft.) |
| | 3B | Drafted Via Rule 5 (The Cleveland Guardians selected INF Deyvison De Los Santos in the Rule 5 Draft.) |
| | RF | Waived (The Cleveland Guardians waived OF Oscar Gonzalez.) |
| | P | Signed (The Cleveland Guardians signed RHP Jaime Barría to a minor league contract.) |
| | P | Signed (The Cleveland Guardians signed RHP Jaime Barría to a minor league contract.) |
| | P | Traded (The San Diego Padres traded RHP Scott Barlow to the Cleveland Guardians.) From |
| | C | Traded (The Colorado Rockies traded C Kody Huff to the Cleveland Guardians.) From |
| | P | Traded (The Cleveland Guardians traded RHP Cal Quantrill to the Colorado Rockies.) To |
| | P | Traded (The Cleveland Guardians traded RHP Enyel De Los Santos to the San Diego Padres.) To |
| | P | Signed (The Cleveland Guardians signed RHP Adam Oller to a minor league contract.) |
| | P | Recalled From Minors Rehab (The Cleveland Guardians selected the contract of RHP Cade Smith from the minors.) |
| | P | Designated for Assignment (The Cleveland Guardians designated RHP Cal Quantrill for assignment.) |
| | P | Designated for Assignment (The Cleveland Guardians designated RHP Michael Kelly for assignment.) |
| | P | Recalled From Minors Rehab (The Cleveland Guardians selected the contract of RHP Daniel Espino from the minors.) |
| | C | Declared Free Agency (C Cam Gallagher elected free agency.) |
| | P | Declared Free Agency (RHP Sergio Morillo declared free agency.) |
| | P | Declared Free Agency (RHP Jerad Eickhoff declared free agency.) |
| | P | Declared Free Agency (RHP Luis Oviedo declared free agency.) |
| | C | Designated for Assignment (The Cleveland Guardians designated C Cam Gallagher for assignment.) |
| | C | Claimed on Unconditional Release Waivers (The Cleveland Guardians claimed C Christian Bethancourt off waivers from the Tampa Bay Rays.) |
| | P | Activated (The Cleveland Guardians activated RHP Tanner Bibee.) |
| | LF | Activated (The Cleveland Guardians activated INF Jhonkensy Noel.) |
| | P | Activated (The Cleveland Guardians activated LHP Joey Cantillo.) |
| | P | Activated (The Cleveland Guardians activated LHP Logan Allen.) |
| | 2B | Activated (The Cleveland Guardians activated INF Angel Martínez.) |
| | RF | Activated (The Cleveland Guardians activated OF George Valera.) |
| | 2B | Activated (The Cleveland Guardians activated OF Gabriel Arias.) |
| | P | Activated (The Cleveland Guardians activated LHP Tim Herrin.) |
| | RF | Recalled From Minors Rehab (The Cleveland Guardians recalled OF Johnathan Rodriguez from the minors.) |
| | 3B | Activated (The Cleveland Guardians activated INF Juan Brito.) |
| | P | Activated (The Cleveland Guardians activated RHP Hunter Gaddis.) |
| | C | Activated (The Cleveland Guardians activated 1B David Fry.) |
| | P | Activated (The Cleveland Guardians activated RHP Cody Morris.) |
| | P | Activated (The Cleveland Guardians activated RHP Michael Kelly.) |
| | C | Declared Free Agency (Cleveland Guardians C Sandy León declared free agency.) |
| | P | Declared Free Agency (Cleveland Guardians RHP Lucas Giolito declared free agency.) |
| | 1B | Claimed on Unconditional Release Waivers (The Cleveland Guardians claimed INF Alfonso Rivas off waivers from the Pittsburgh Pirates.) |
| | RF | Declared Free Agency (Cleveland Guardians OF Kole Calhoun declared free agency.) |
| | P | Declared Free Agency (Cleveland Guardians RHP Reynaldo López declared free agency.) |
| | P | Declared Free Agency (RHP Zach Plesac declared free agency.) |
| | P | Declared Free Agency (RHP Chris Vallimont declared free agency..) |
| | P | Released (The Cleveland Guardians released LHP Daniel Norris.) |
| | C | Released (The Cleveland Guardians released C Zack Collins.) |
| | C | Released (The Cleveland Guardians released C Eric Haase.) |
| | RF | Recalled From Minors Rehab (The Cleveland Guardians recalled OF Oscar Gonzalez from the minors.) |
| | C | Placed on Paternity Leave List (The Cleveland Guardians placed INF David Fry on the Paternity Leave list.) |
| | 2B | Placed on 10-Day IL (The Cleveland Guardians placed OF Gabriel Arias on the 10-day injured list with a right wrist fracture.) |
| | SS | Recalled From Minors Rehab (The Cleveland Guardians recalled INF Brayan Rocchio from the minors.) |
| | P | Sent to Minors (The Cleveland Guardians optioned RHP Michael Kelly to the minors.) |
| | P | Activated (The Cleveland Guardians activated RHP Triston McKenzie from the 60-day injured list.) |
| | P | Placed on 60-Day IL (The Cleveland Guardians placed RHP Tanner Bibee on the 60-day injured list.) |
| | P | Recalled From Minors Rehab (The Cleveland Guardians recalled RHP Michael Kelly from the minors.) |
| | P | Placed on 15-Day IL (The Cleveland Guardians placed LHP Logan Allen on the 15-day injured list with left shoulder inflammation. ) |
| | P | Sent to Minors (The Cleveland Guardians optioned RHP Hunter Gaddis to the minors.) |
| | P | Activated (The Cleveland Guardians activated RHP Shane Bieber from the 60-day injured list.) |
| | P | Sent to Minors (The Cleveland Guardians optioned RHP Michael Kelly to the minors.) |
| | P | Recalled From Minors Rehab (The Cleveland Guardians recalled RHP Hunter Gaddis from the minors.) |
| | P | Activated (The Cleveland Guardians activated RHP Michael Kelly from the 15-day injured list.) |
| | P | Placed on 15-Day IL (The Cleveland Guardians placed RHP Tanner Bibee on the 15-day injured list.) |
| | P | Recalled From Minors Rehab (The Cleveland Guardians recalled RHP James Karinchak from the minors.) |
| | C | Sent to Minors (The Cleveland Guardians sent C Eric Haase outright to the minors.) |
| | 1B | Activated (The Cleveland Guardians activated INF Josh Naylor from the 10-day injured list.) |
| | RF | Sent to Minors (The Cleveland Guardians optioned OF Oscar Gonzalez to the minors.) |
| | P | Sent to Minors (The Cleveland Guardians sent LHP Daniel Norris outright to the minors.) |
| | P | Activated (The Cleveland Guardians activated RHP Lucas Giolito.) |
| | P | Sent to Minors (The Cleveland Guardians optioned RHP James Karinchak to the minors.) |
| | P | Recalled From Minors Rehab (The Cleveland Guardians recalled RHP Reynaldo López from the minors.) |
| | P | Sent to Minors (The Cleveland Guardians optioned RHP Cody Morris to the minors.) |
| | C | Activated (The Cleveland Guardians activated INF David Fry from the 10-day injured list.) |
| | P | Sent to Minors (The Cleveland Guardians optioned RHP Hunter Gaddis to the minors.) |
| | P | Recalled From Minors Rehab (The Cleveland Guardians recalled LHP Matt Moore from the minors.) |
| | SS | Recalled From Minors Rehab (The Cleveland Guardians recalled INF José Tena from the minors.) |
| | P | Activated (The Cleveland Guardians activated RHP Cal Quantrill from the 15-day injured list.) |
| | RF | Traded (The Cleveland Guardians traded OF Chris Roller to the Milwaukee Brewers.) To |
| | P | Claimed on Unconditional Release Waivers (The Cleveland Guardians claimed LHP Matt Moore off waivers from the Los Angeles Angels.) |
| | P | Designated for Assignment (The Cleveland Guardians designated RHP Peyton Battenfield for assignment.) |
| | P | Claimed on Unconditional Release Waivers (The Cleveland Guardians claimed RHP Reynaldo Lopez off waivers from the Los Angeles Angels.) |
| | C | Designated for Assignment (The Cleveland Guardians designated C Eric Haase for assignment.) |
| | P | Claimed on Unconditional Release Waivers (The Cleveland Guardians claimed RHP Lucas Giolito off waivers from the Los Angeles Angels.) |
| | P | Released (The Cleveland Guardians released RHP Noah Syndergaard.) |
| | P | Recalled From Minors Rehab (The Cleveland Guardians recalled RHP Hunter Gaddis from the minors.) |
| | P | Designated for Assignment (The Cleveland Guardians designated LHP Daniel Norris for assignment.) |
| | P | Recalled From Minors Rehab (The Cleveland Guardians selected the contract of LHP Daniel Norris from the minors.) |
| | P | Designated for Assignment (The Cleveland Guardians designated RHP Noah Syndergaard for assignment.) |
| | P | Recalled From Minors Rehab (The Cleveland Guardians recalled RHP Cody Morris from the minors.) |
| | P | Sent to Minors (The Cleveland Guardians returned RHP Hunter Gaddis to the minors.) |
| | P | Sent to Minors (The Cleveland Guardians optioned LHP Tim Herrin to the minors.) |
| | C | Sent to Minors (The Cleveland Guardians sent C Zack Collins outright to the minors.) |
| | SS | Sent to Minors (The Cleveland Guardians optioned INF Brayan Rocchio to the minors.) |
| | C | Activated (The Cleveland Guardians activated C Cam Gallagher from the 7-day injured list.) |
| | P | Recalled From Minors Rehab (The Cleveland Guardians recalled RHP Hunter Gaddis from the minors as the 27th man for Thursday's (Aug. 24) doubleheader. ) |
| | P | Declared Free Agency (LHP Amir Garrett elected free agency. ) |
| | P | Signed (The Cleveland Guardians signed LHP Daniel Norris to a minor league contract.) |
| | P | Signed (The Cleveland Guardians signed LHP Daniel Norris to a minor league contract.) |
| | C | Activated (The Cleveland Guardians activated C Eric Haase.) |
| | C | Claimed on Unconditional Release Waivers (The Cleveland Guardians claimed C Eric Haase off waivers from the Detroit Tigers.) |
| | C | Designated for Assignment (The Cleveland Guardians designated C Zack Collins for assignment.) |
| | P | Declared Free Agency (LHP Daniel Norris declared free agency.) |
| | P | Sent to Minors (The Cleveland Guardians returned RHP Hunter Gaddis to the minors.) |