The left-hander makes his first home start since throwing the club’s 16th no-hitter in the finale of a three-game set against the Los Angeles Angels on Sunday.
Buehrle (2-0, 2.59 ERA) will go for a third straight win as he makes his second start since tossing the no-hitter against Texas on April 18.
In his first outing after tossing the gem, Buerhrle was effective, allowing three runs and five hits in seven innings of a 7-4 win at Kansas City on Monday.
“I did a lot better than I thought I was going to do, just coming off a no-hitter,” said Buehrle, who is 1-3 with a 4.16 ERA in 12 games with 11 starts against the Angels. “I thought something crazy was going to happen. I’d go out and give up 10 hits or get beat around a little bit.”
Buehrle is off to a solid start in 2007 after going 3-7 with a 6.44 ERA in the second half of 2006.
“It’s good to see he has his stuff back,” first baseman Paul Konerko said. “He’s throwing the ball right now as well as any point probably as a White Sox.”
Chicago (12-10) could use another strong outing from Buehrle as it tries to bounce back from a 3-0 loss to Los Angeles (13-11) on Saturday.
One night after beating the Angels 7-3 win in the series opener, the White Sox were shutout for the second time in 2007. Los Angeles’ Jered Weaver and three relievers combined on an eight-hitter and struck out nine for the Angels, who have won seven of nine.
The White Sox will be without slugger Jim Thome who was placed on the disabled list Saturday after re-aggravating a rib injury Friday that held him out of two games prior to that. The designated hitter has a team-leading .340 average with five homers and 10 RBIs.
“We can do one of those deals where we keep him out for three or four days,” Chicago general manager Ken Williams said. “But what we decided was we’ve got a good enough balance in our team where we should be able to hold the fort until he returns completely 100 percent healthy and we don’t get one of these lingering things that last until the end of May or June.”
Kelvim Escobar (1-1, 3.71) will make his second start for the Angels since coming off the disabled list with shoulder irritation. The right-hander allowed three earned runs and five hits in 5 2-3 innings, but did not earn a decision in Los Angeles’ 9-8 win in 10 innings over Detroit on Tuesday.
“I felt strong the whole way,” Escobar told the Angels’ official Web site. “It wasn’t like I was all over the place with the ball. I was very close on so many pitches.”
Escobar is 2-9 with a 5.93 ERA in 19 games against Chicago, including 10 starts.
The Angels’ Gary Matthews Jr. went 1-for-4 with a lead-off homer to extend his hitting streak to eight games in which he is hitting .441 (15-for-34) with seven RBIs.
Los Angeles left fielder Garret Anderson is likely to miss a second straight game because of a tight right hip flexor.
“We’re going to take it day-to-day and make sure this thing is at a level where he is not going to be a high risk,” said Angels manager Mike Scioscia of Anderson, who is 5-for-11 with four RBIs and four runs scored in his last three games.