Most skincare products are intended for particular skincare challenges and skin types, but Pitera Essence is not your average product. Its formula is made up almost completely (90 percent!) of SK-II’s natural bio-ingredient, Pitera. Derived from yeast fermentation, Pitera refines both skin texture and appearance and is exclusively cultured in Japan for SK-II. The essence was formulated after an exhaustive number of studies were conducted among millions of yeast strains and hundreds of fermentation conditions, which is why SK-II’s cultivation method remains one of the company’s most coveted trade secrets.