What is it?
A battle of the big guns. Reigning champions Manchester City against potential title contenders Chelsea. Frank Lampard's young Blues side have impressed and currently sit third in the table, a point ahead of Pep Guardiola's men.
With Liverpool already nine points in front of City at the top of the standings, they cannot afford another slip-up.
When is it?
Saturday, November 23.
What time is kick-off?
What TV channel is it on?
Sky Sports Main Event and Sky Sports Premier League from 5pm.
Watch Manchester City v Chelsea through NOW TV with a Sky Sports Pass for just £20 a month for 6 months
What are the current standings?
What is the team news?
What are they saying?
Frank Lampard revealed he sent Jose Mourinho a good-luck message ahead of the Portuguese boss taking charge of Tottenham for the first time:
"We had a couple of messages just to wish him well in his new role as he has always done for me.
"I think history and results speak for themselves; the trophies, titles he's managed to win at clubs, they are not surprises, they are for the hard work he's put in. He's done that consistently.
"Everywhere you go it's a new beginning, I don't think you can rely on that.
"But people will hold up his record and expect big things from him."
Lampard has insisted he will never follow Mourinho's lead and manage Tottenham:
"I can firmly say no, and you can replay that again in 10 years.
"It wouldn't happen but I think things are different for me.
"I was here for 13 years as a player and have an absolutely deep feeling for a club.
"Chelsea is certainly so close to my heart hence why I am so proud to manage the club and why I wouldn't manage Tottenham.
"That's no disrespect to anyone, it's just because of what Chelsea has given me over my time as a player and now, it's certainly not on my list."
What are the odds?
Manchester City - 2/5
Draw - 4/1
Chelsea - 6/1
What's our prediction?
Chelsea are flying high, winning their last five Premier League games, and Man City are coming off the back of a 3-1 loss to title rivals Liverpool. But, as impressive as Chelsea have been, City are a different beast altogether, especially at home.
Predicted score: Manchester City 3 Chelsea 1.