It took a couple of minutes for Louisville coach Bobby Petrino to run through all the injuries - and update on injured players - during Monday's press conference.
No spot has been hit harder than running back.
Louisville has been without four of its top five running backs at some point this season - save for only Reggie Bonnafon, who is a converted wide receiver/quarterback who switched to RB after injuries in Spring Practice.
"Colin is out for the rest of the year," Petrino confirmed Monday. Wilson got injured during a carry against Murray State.
And Louisville's standout back against North Carolina, Malik Williams, is now out after getting injured at NC State Thursday night.
"Malik is probably going to be out for a while," Petrino confirmed.
Dae Williams hasn't played a down yet this season, but it looks like he may get in the lineup either this week or next.
"Dae Williams has been cleared," Petrino said. "So we will get him into contact practice this week. He's actually been out there practicing for three weeks, but he just got cleared late last week. We'll see how that goes."
So who else can play running back for the Cardinals for the second half of the season?
"We got Reggie, we've got Trey Smith who came in and played pretty well a couple of weeks ago," Petrino said. "Trey has been with us for a long time. He understands all of the coverages and he's got good hands. He can catch the ball out of the backfield."
"Tobias Little has been working at both fullback and tailback. He's a guy who can really run, catch the ball in his hands. So we'll just keep going."