Leonard will make his second appearance this season though coach Frank Reich said Friday that Leonard will be on a pitch count.
He missed the first three games following offseason back surgery and played one half against Tennessee on Oct. 2 before suffering a concussion and fractured nose in a violent collision with a teammate.
Ryan, the 2016 league MVP, has started 229 games and is sitting out for just the fourth time in his 15-year career. Reich said Monday he was benching Ryan following a two-interception game in the rematch with the AFC South-leading Titans. Ryan suffered a separated throwing shoulder, which Reich said had no impact on the decision. Ryan has thrown a league-high nine interceptions this season. He also has a league-high 12 turnovers entering Week 8.
Second-year quarterback Sam Ehlinger will make his starting debut for Indy (3-3-1).
The Commanders (3-4) will be without their top tackler in Cole Holcomb. He's out with an injured foot.
More AP NFL coverage: https://apnews.com/hub/NFL and https://twitter.com/AP-NFL