Las Vegas Raiders at Los Angeles Chargers: Predictions, picks and odds for NFL Week 4 game

The Los Angeles Chargers (1-2) have their first divisional matchup of the season as they host the Las Vegas Raiders (1-2) on Sunday at SoFi Stadium.

The Chargers opened the season with two dramatic losses and finally got a win in Week 3 against the Minnesota Vikings. This week, they will be without wide receiver Mike Williams, who suffered a torn ACL. Austin Ekeler may or may not return from an ankle injury and there is drama off the field as there was an arrest warrant out on Pro Bowl defender JC Jackson.

The Raiders, under new quarterback Jimmy Garoppolo, started strong against AFC West foe Denver Broncos, but have struggled since. Garoppolo went into concussion protocol after a Sunday night loss to the Pittsburgh Steelers and could miss this matchup.

Los Angeles and Las Vegas have split their games every year since 2020, the Raiders' first season in Sin City. In their last matchup, the Raiders won 27-20 behind two touchdowns from Davante Adams of 31 and 45 yards.

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Chargers vs. Raiders odds, moneyline, over/under

The Chargers are favorites to defeat the Raiders, according to the BetMGM NFL odds. Looking to wager? Check out the best mobile sports betting apps offering NFL betting promos in 2023.

  • Spread: Chargers (-4.5)

  • Moneyline: Chargers (-225); Raiders (+185)

  • Over/under: 48.5

Not interested in this game? Our guide to the NFL betting odds, picks and spreads has you covered with Thursday Night Football odds, Sunday Night Football odds and/or Monday Night Football odds.

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Sep 11, 2022; Inglewood, California, USA; Las Vegas Raiders wide receiver Davante Adams (17) is pursued by Los Angeles Chargers cornerback Michael Davis (43) in the first half at SoFi Stadium. Mandatory Credit: Kirby Lee-USA TODAY Sports
Sep 11, 2022; Inglewood, California, USA; Las Vegas Raiders wide receiver Davante Adams (17) is pursued by Los Angeles Chargers cornerback Michael Davis (43) in the first half at SoFi Stadium. Mandatory Credit: Kirby Lee-USA TODAY Sports

NFL Week 4 odds, predictions and picks

Packers vs. Lions | Jaguars vs. Falcons | Bills vs. Dolphins | Panthers vs. Vikings | Bears vs. Broncos | Browns vs. Ravens | Texans vs. Steelers | Colts vs. Rams | Saints vs. Buccaneers | Eagles vs. Commanders | Titans vs. Bengals | Chargers vs. Raiders | Cowboys vs. Patriots | 49ers vs. Cardinals | Jets vs. Chiefs | Giants vs. Seahawks

Lorenzo Reyes: Chargers 30, Raiders 20

Los Angeles has been in close games so far this season, with the average margin of victory or defeat being just three points. The offense can put up points, but the defense yields a ton of yardage. I like the Chargers to cover here, however, because they protect the ball (just one giveaway this season) and the Raiders are yet to force a turnover and are tied for NFL worst -7 turnover differential.

Tyler Dragon: Chargers 27, Raiders 20

Raiders fans are going to vastly outnumber Chargers fans Sunday at SoFi Stadium. However, the plethora of Raiders fans are going to go home unhappy after the Chargers improve to .500 on the season. The Chargers have the NFL’s second ranked offense. LA’s poor defense might get a break this week if Raiders QB Jimmy Garoppolo remains in concussion protocol.

Victoria Hernandez: Chargers 27, Raiders 17

Justin Herbert will be missing Mike Williams — the Chargers' second-leading receiver — and the JC Jackson situation could be a tough distraction. But even if Los Angeles is missing a few more pieces than they'd like, the team still has more together than the Raiders.

Jordan Mendoza: Chargers 33, Raiders 24

It’ll be a home game for the Raiders in Los Angeles, but the fans won’t be able to will the offense to match the high-powered Chargers. Justin Herbert rips up the Las Vegas defense for a convincing win.

You can view the full list of USA TODAY's NFL expert predictions here.

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This article originally appeared on USA TODAY: Las Vegas Raiders at Los Angeles Chargers: Game predictions, picks, odds