The Lady Vols led, 46-30, at halftime.
Five Tennessee players scored 10-plus points and two Lady Vols recorded a double-double.
Destinee Wells recorded 18 points and eight assists, while Sara Puckett finished with 14 points and eight rebounds for the Lady Vols.
Tennessee outscored the Trojans, 25-9, after the two teams were tied, 21-21, after the first quarter.
Kaiya Wynn had 10 points and five rebounds for Tennessee.
Tennessee will next play Indiana on Thursday in Fort Myers, Florida (6 p.m. EST, Fox).