Joseph was listed as questionable on Friday after popping up on the injury report on Thursday. A hamstring injury is the reason why Joseph will miss the game. Ronnie Harrison will start in his place.
Joseph has 23 tackles, an interception and a forced fumble in four starts this season.
Linebacker Darius Leonard and left tackle Anthony Castonzo were ruled out for Indy. Quarerback Jacob Eason, defensive tackle Eli Ankou, wide receiver Dezmon Patmon, tight end Noah Togiai, and defensive lineman Ron’Dell Carter are inactive as well.