Lucas Tousart's goal back in February gave Lyon a precious lead, but they arrive in Turin cold having only played one competitive match in the past five months, losing to PSG in the French League Cup final. Juve have since clinched Serie A and have Cristiano Ronaldo fit and firing after he was rested against Roma in their final game of the season, although manager Maurizio Sarri is said to be under pressure and is in need of a result here.
Either Real Madrid or Manchester City await in the quarter-finals. Follow all the live action below:
How can I watch it online and on TV?
The game will be broadcast live on BT Sport 2 and BT Sport Extra 2.
Subscribers can also stream the match on the BT Sport website and app.
Juventus are without Douglas Costa, while Paulo Dybala is a doubt. If he’s fit, he’ll play though in such a key game. Mattia De Sciglio is also injured.
Lyon welcomed back Memphis Depay to action in their cup final loss at the weekend, but Kenny Tete is unlikely to play and Marcelo is a doubt.
Juventus: Szczesny; Cuadrado, De Ligt, Bonucci, Sandro; Pjanic, Bentancur, Rabiot; Bernardeschi, Dybala, Ronaldo.
Lyon: Lopes; Denayer, Marcelo, Marcal; Dubois, Caqueret, Mendes, Aouar, Cornet; Memphis, Dembele.
Juventus — 5/11
Draw — 19/5
Lyon — 38/5