INDIANAPOLIS (AP) When Jalen Hurts saw the middle of the field open up, he tucked the ball and ran.
A few minutes later, the Philadelphia Eagles' Super Bowl quest was back in high gear, too.
Six days after Philly lost its first game of the season, Hurts scored on an 8-yard touchdown run with 1:20 to play, and the Eagles rallied for a 17-16 win over the Indianapolis Colts on Sunday.
''(Coach) Nick (Sirianni) just kept telling me to be who I am,'' Hurts said. ''Some things weren't going our way, but I felt there was never a doubt.''
He certainly played fearlessly.
Hurts repeatedly kept the ball in his hands on short-yardage plays and delivered often - with a little help from teammates who sometimes literally pushed him past the first-down marker. And when the Eagles needed to make big plays, Hurts didn't flinch.
The third-year quarterback went 18 of 25 with 190 yards through the air, throwing for one score early in the fourth quarter to cut the deficit to 13-10, before capping his 16-carry, 86-yard rushing day with the decisive score. It was the first time since 2010 - a span of 44 games - that Philadelphia (9-1) won after starting the fourth quarter down by double digits.
The Eagles won their seventh straight road game.
''You put the ball in the hands of players you need a big moment from,'' Sirianni said. ''Jalen took it from there.''
Indianapolis (4-6-1) never trailed until Hurts' final run as interim coach Jeff Saturday fell to 1-1 since replacing the fired Frank Reich.
But while the Colts held Philadelphia to its lowest point total since a 13-7 loss to the New York Giants last Nov. 28, they struggled to contain Hurts.
When the Eagles lined up with less than 90 seconds to play and four receivers spread across the field, Hurts read the defense and sprinted straight to the end zone before Indy's defense could react.
''Ultimately, they made one more play than we did,'' Saturday said. ''I thought our defense was playing good, playing good enough to win.''
Indy had one last shot but the drive stalled before it reached midfield.
For most of the day, the Colts played well. They drove 75 yards on their opening possession, taking a 7-0 lead on Jonathan Taylor's 1-yard run - Indy's first TD on its first possession since last Dec. 25.
The Colts could only muster three more field goals by Chase McLaughlin. His 51-yard attempt that missed to the right set up Philadelphia's first TD - a 22-yard pass from Hurts to Quez Watkins with 13:31 left in the game.
The Colts made it 16-10 on McLaughlin's third field goal of the day with 4:37 to go, but Hurts drew a 39-yard pass-interference call on Zaire Franklin and called his own number nine plays later.
''That's a tough one to swallow,'' said Colts quarterback Matt Ryan, who played high school football near Philadelphia. ''Make no mistake, that's a good football team. We did a lot of really good things, but we made too many mistakes and that one feels like we let it get away.''
Eagles: Miles Sanders had 13 carries for 47 yards. ... DeVonta Smith finished with six receptions for 78 yards and A.J. Brown had five catches for 60 yards. ... The Eagles sacked Ryan five times including on third-and-9 in the final minute. ... Philadelphia has beaten Indy four consecutive times in the series.
Colts: Ryan was 23 of 32 with 213 yards and passed Hall of Famer Dan Marino for No. 6 on the NFL's career list for passing attempts. Ryan's total of 8,359 is one more than Marino. ... Taylor carried 22 times for 84 yards and scored for the second straight week. ... Michael Pittman Jr. caught six passes for 75 yards and Parris Campbell had five receptions for 67 yards. ... Backup quarterback Nick Foles was inactive against the team he led to the Super Bowl 52 title.
As Sirianni entered the locker room, he was seen wiping tears from his eyes. It was Sirianni's first game back in Indy since he left Reich's staff to take the Philadelphia job following the 2020 season. Sirianni said he was touched by the reactions from the players he coached from 2018-20 - and the absence of Reich.
''It was good see some familiar faces to guys I coached,'' he said. ''But you don't want to know what I think about him (Reich) not being here.''
Eagles: Return home next Sunday to face Green Bay.
Colts: Host Pittsburgh on Monday, Nov. 28.
More AP NFL: https://apnews.com/hub/nfl and https://twitter.com/AP-NFL