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Jacksonville Jaguars at Tampa Bay Buccaneers picks, predictions: Who wins in NFL Week 16?

The Jacksonville Jaguars and Tampa Bay Buccaneers play on Sunday, Dec. 24 at Nissan Stadium in a game on the NFL Week 16 schedule.

Which team will win the Week 16 NFL game?

Check out these NFL Week 16 picks and NFL Week 16 predictions for the game, which can be seen at 2:05 p.m. MST on CBS (stream with free trial from FUBO).

The Jaguars are a 2.5-point favorite over the Buccaneers in NFL Week 16 odds for the game, courtesy of BetMGM Sportsbook.

Jacksonville is -140 on the moneyline, while Tampa Bay is +120.

The over/under (point total) is set at 44.5 points.

The Jaguars are coming off a 23-7 loss against the Baltimore Ravens in their NFL Week 15 game.

The Buccaneers are coming off a 34-20 win against the Green Bay Packers.

NFL Week 16 picks: Saints at Rams | Bengals at Steelers | Bills at Chargers | Colts at Falcons | Packers at Panthers | Browns at Texans | Lions at Vikings | Commanders at Jets | Seahawks at Titans | Jaguars at Buccaneers | Cardinals at Bears | Cowboys at Dolphins | Patriots at Broncos | Raiders at Chiefs | Giants at Eagles | Ravens at 49ers | Power rankings | Odds | Schedule

The Arizona Republic: Buccaneers 24, Jaguars 19

Jeremy Cluff writes: "The Jaguars are favored on the road. We're not buying it. Tampa Bay is on the rise, while Jacksonville is struggling."

NFL Week 16 picks, predictions: Predicting Ravens-49ers, Cowboys-Dolphins, other games

Bookies.com: Bet the Buccaneers on the moneyline vs. Jaguars

Bill Speros writes: "Florida NFL fans have landed on the 'Nice' list as all three NFL teams in the Sunshine State are in first place as the season hits Christmas Weekend. The Buccaneers rolled over the Packers in Green Bay in Week 15, in Baker Mayfield's best performance of his career, as he finished with a perfect passer rating in a dominant 34-20 win. Jaguars' QB Trevor Lawrence landed in concussion protocol after taking a beating at the hands of the Ravens Sunday night. His replacement on Sunday would be C.J. Beathard. Either way, the Buccaneers defense will be the difference in this one."

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Sports Betting Dime: Jaguars 21.8, Buccaneers 18.1

The site's formula predicts that the Jaguars will win the NFL Week 16 game against the Buccaneers.

NFL Week 16 odds: Point spreads, moneylines, over/unders for betting on games

Will Baker Mayfield and the Tampa Bay Buccaneers beat the Jacksonville Jaguars on Sunday? NFL Week 16 picks, predictions and odds for the game.
Will Baker Mayfield and the Tampa Bay Buccaneers beat the Jacksonville Jaguars on Sunday? NFL Week 16 picks, predictions and odds for the game.

ESPN: Jaguars have a 57.4% chance to beat Buccaneers on Sunday

The site gives the Buccaneers a 42.2% shot at winning the Week 16 NFL game.

NFL Week 16 schedule: Television channels, how to watch, stream games this week

Pro Football Network: Take Buccaneers with the points vs. Jaguars in NFL Week 16

David Bearman writes: "I expect this to be a close one and give the edge to Baker Mayfield and the Bucs at home with the points, especially if Trevor Lawrence does not clear concussion protocol."

STREAM THE GAME: Watch Jaguars at Buccaneers live with FUBO (free trial)

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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.

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This article originally appeared on Arizona Republic: Jacksonville Jaguars at Tampa Bay Buccaneers picks for NFL Week 16