The Jaguars are riding high after a decisive victory over the Los Angeles Chargers in Week 3, but can Lawrence and Co. stay on their game against perhaps their toughest opponent on the 2022 NFL regular season? It might be the highest-stakes game yet for Lawrence in the NFL. The game kicks off Sunday at 1 p.m. from Lincoln Financial Field.
Here's a look at the betting details and USA TODAY's NFL staff picks for the Jaguars vs. Eagles Week 4 game:
Jaguars at Eagles odds, moneyline and over/under
Spread: Eagles (-6.5)
Moneyline: Eagles (-280); Jaguars (+230)
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NFL Week 4 odds, predictions and picks
Dolphins vs. Bengals | Vikings vs. Saints | Browns vs. Falcons | Seahawks vs. Lions | Jaguars vs. Eagles | Commanders vs. Cowboys | Titans vs. Colts | Jets vs. Steelers | Bills vs. Ravens | Chargers vs. Texans | Bears vs. Giants | Cardinals vs. Panthers | Patriots vs. Packers | Broncos vs. Raiders | Chiefs vs. Buccaneers | Rams vs. 49ers
Lorenzo Reyes: Eagles 30, Jaguars 26
For a young team, confidence can work wonders. And while that works for both teams in this matchup, the Jaguars appear to be hitting a stride behind the improvement of Trevor Lawrence. I still like the Eagles on the moneyline, but with Jacksonville leading the league in turnover margin (+7), I think it has a good shot to cover.
Safid Deen: Eagles 28, Jaguars 24
This could be a sneaky good and entertaining matchup between two young NFL quarterbacks. Jalen Hurts has command of the Eagles offense. an has Philly off to a 3-0 start this season, while the Jaguars surprised many with their 2-1 start and blowout win on the road against the Chargers last week. I’m just not ready to give the Jaguars the edge or benefit of the doubt yet. I like the Eagles to improve to 4-0 at home this week.
Lance Pugmire: Jaguars 27, Eagles 24
If the Colts’ shutout/blowout of Chargers wasn’t enough, this becomes their coming-out party. A lively defense, thunderous ground game and vastly improved Trevor Lawrence are for real.
Jarrett Bell: Eagles 27, Jaguars 24
Nate Davis: Eagles 23, Jaguars 20
Tyler Dragon: Eagles 30, Jaguars 20
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This article originally appeared on USA TODAY: Jacksonville Jaguars at Philadelphia Eagles: Game odds, picks, predictions