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Here is the 2021 NFL schedule for the Indianapolis Colts. Week 1: vs. Seattle Seahawks Week 2: vs. Los Angeles Rams Week 3: @ Tennessee Titans Week 4: @ Miami Dolphins. Week 5: @ Baltimore Ravens Week 6: vs. Houston Texans Week 7: @ San Francisco 49ers Week 8: vs. Tennessee Titans. Week 9: vs. New York Jets Week 10: vs. Jacksonville Jaguars Week 11: @ Buffalo Bills Week 12: vs. Tampa Bay Buccaneers Week 13: @ Houston Texans. Week 14: Bye Week 15: vs. New England Patriots Week 16: @ Arizona Cardinals Week 17: vs. Las Vegas Raiders Week 18: @ Jacksonville Jaguars