The over/under opened at 39.5 total points with the money line an unbettable Giants +700, Cowboys -1100, per BetMGM.
The Giants are coming off a deflating 30-6 loss to the Raiders in Las Vegas, a game that saw them lose starting quarterback Daniel Jones to a knee injury, possibly for the season.
Dallas lost to the NFC East-leading Eagles in Philadelphia, 28-23, on Sunday and now sit two and a half games off the division lead.
This will be the second meeting between the Giants and Cowboys this season. Dallas won, 40-0, in Week 1 at MetLife Stadium.
The Cowboys have won 12 of the 13 meetings with the Giants going back to the 2017 season.