Sheffield (foot) and Harris (ankle) were ruled out Friday after missing practice all week. Rookie defensive tackle Marlon Davidson (knee) was listed as questionable.
Sheffield, coming off a solid rookie season in which he made 11 starts, is a key member of the youthful cornerback rotation behind starters Isaiah Oliver and first-round pick A.J. Terrell. The absence of Sheffield means more playing time for Darqueze Dennard and Blidi Wreh-Wilson.
Harris was listed as a third-string end behind Takk McKinley and Allen Bailey,
More AP NFL: https://apnews.com/NFL and https://twitter.com/AP-NFL