The visitors have not won in south west London in the Six Nations since 2012 and have only two wins in the past seven meetings between the two sides.
The teams go into Saturday’s highly-anticipated match on the back of two contrasting opening-weekend results. England edged Italy 27-24 in Rome, while a thrilling Wales comeback against Scotland fell just short, the hosts losing 27-26 in Cardiff.
Warren Gatland has named his Wales team already, a day earlier than expected, making seven changes to his starting line-up. You can see Wales’ full matchday 23 below.
When is England v Wales?
England and Wales meet on Saturday, February 10. The match kicks off at 4.45pm (GMT).
Where is England v Wales taking place?
Twickenham, the home of English rugby.
How to watch England v Wales on TV
The match will be broadcast live on ITV.
Who is the referee?
The match will be refereed by New Zealander James Doleman.
What is the latest team news?
Warren Gatland has made seven changes to his starting line-up for Saturday’s clash.
Centre George North returns from injury for his 50th Six Nations appearance, lining up alongside Nick Tompkins in midfield.
Fly-half Sam Costelow, who went off injured during the first-half of Wales’ 27-26 loss to Scotland, is replaced by Ioan Lloyd, with Tomos Williams at scrum-half.
Gatland has also selected a new front-row of Gareth Thomas, Elliot Dee and Keiron Assiratti, with Cardiff flanker Alex Mann handed a first Wales start following his try-scoring appearance off the bench against Scotland.
Uncapped Bath prop Archie Griffin has been named on the bench, where he is joined by Racing 92 lock Will Rowlands.
Rowlands linked up with the Wales squad earlier this week after his partner recently gave birth, while there are also chances among the replacements for Dragons pair Taine Basham and Cai Evans, who is the son of former Wales captain Ieuan Evans.
North has recovered from a shoulder problem to face England, with Lloyd now starting following an outstanding contribution after taking over from Costelow against Scotland.
Mann’s promotion to the starting line-up was expected following Botham’s withdrawal from the squad because of a knee injury.
Williams, Dee and Assiratti, meanwhile, all made major contributions after being introduced for the second 40 minutes last Saturday.
Wales XV: Winnett; Dyer, North, Tompkins, Adams; Lloyd, Williams; G Thomas, Dee, Assiratti, Jenkins (capt), Beard, Mann, Reffell, Wainwright.
Replacements: Elias, Domachowski, Griffin, Rowlands, Basham, Hardy, Evans, Grady.
England remain optimistic that Ellis Genge will recover from a foot injury to face Wales and hope to welcome Ollie Lawrence back to training this week.
Lawrence, ruled out of the beginning of this Six Nations due to a hip issue, will not be available to feature this weekend. He and George Martin are targeting the Calcutta Cup encounter against Scotland on February 24.
That game will come too early for Marcus Smith, however, whose prospects of featuring in this Six Nations seem bleak.
Wales have released flanker James Botham from their Six Nations squad to face England due to a knee injury, but there are recalls for tighthead prop Dillon Lewis and Seb Davies, who can cover lock and loose-forward.
Botham, the grandson of former England cricket all-rounder Ian, sparked Wales’ remarkable comeback against Scotland in his first Test in almost three years in Cardiff on Saturday.
He barged over for the side’s first try as they scored 26 unanswered points but fell agonisingly short in a thrilling 27-26 defeat.
The length of his absence is unknown, with Welsh Rugby confirming he will return to his club Cardiff to continue his rehabilitation.
Davies has been called to cover the back row having trained with the team last week, though he was not officially a part of the squad then.
Lewis comes into contention after Leon Brown went off at half-time against the Scots with a knock, though the latter remains with the team for now.
Wales do have two other tightheads in Keiron Assiratti, who has three international appearances, and uncapped Archie Griffin. Lewis is a veteran of 54 caps and adds experience in that position.
The youthful selection are seeking a first win against England at Twickenham since the 2015 Rugby World Cup, and a first Six Nations success in London for 12 years.
Steve Borthwick will name his team tomorrow (Thursday).
When did England and Wales last win the Six Nations?
England last won the Six Nations in 2020, with Wales winning the title a year later in 2021.
England’s last Grand Slam was in 2016 and Wales’ was in 2019.
England’s last Triple Crown was in 2020. Wales’ was in 2021.
England and Wales’ Six Nations squads
What was the score last year?
Last year’s Six Nations saw England beat Wales in Cardiff, 20-10.
What are the latest odds?
England to win: 2/9
Wales to win: 23/5