The Sparks announced the move Wednesday, five days after longtime WNBA coach Brian Agler resigned.
''I'm excited to be the new head coach of the LA Sparks,'' Fisher said in a team statement. ''There is no finer organization in the WNBA and I can't wait to work with our ownership group, front office, talented players and staff to cement a culture of sustained excellence, which is what LA basketball fans demand - and deserve.''
The 44-year-old Fisher is being welcomed by two-time MVP Candace Parker.
''Derek is a great basketball mind who brings a ton of high-level experience to our team,'' Parker said. ''I look forward to working with someone with championship pedigree and who has a track record of strong leadership. Derek has been a strong supporter of women's basketball for quite some time, so it's nice to officially welcome him.''
Agler guided LA to the 2016 WNBA title and had an 85-51 record with the Sparks in four seasons. The team is owned by an investment group led by Magic Johnson and Mark Walter, owner of the Los Angeles Dodgers.