Alabama junior running back Bo Scarbrough crossed the goal-line with 6:16 remaining in the first quarter to give the Crimson Tide an early 7-0 lead.
It was only the beginning of a day that the Commodores would rather forget as Alabama steam-rolled their way to a 59-0 win.
Alabama was dominant up front throughout the game, accumulating 677 total yards of offense, 496 of those coming on the ground.
On the flip side, it couldn't have been a worse showing for Vanderbilt on both sides of the ball. Offensively, the Commodores could only muster a lowly 78 yards of offense.
The Crimson Tide was lead offensively by junior running back Damien Harris, who finished with 151 rushing yards and three touchdowns while averaging 12.6 yards per carry.
Vanderbilt was led offensively by senior running back Ralph Webb, who finished with just 20 yards rushing.
The Commodores fall to 3-1 on the season and will have a week to lick their wounds before traveling to Florida next Saturday.